External validation of a model for periconceptional prediction of recurrent early-onset preeclampsia

S.M. van Kuijk, D.H. Delahaije, C. Dirksen, H.C. Scheepers, M.E. Spaanderman, W. Ganzevoort, J.J. Duvekot, M.A. Oudijk, M.G. van Pampus, P. von Dadelszen, L.L. Peeters, the PreCare study group, L.J. Smits

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To validate a previously published prediction model for recurrent early-onset preeclampsia (PE). Methods: We included 229 pregnant women with a history of early-onset PE and computed their risk using the prediction model, compared the predicted risk to their pregnancy outcomes and assessed performance of the model. Results: Early-onset PE recurred in 6.6% of participants. The area under the receiver operating characteristic curve was 59% (95% CI: 45-73). The model created groups that were only moderately different in terms of their risk. Conclusions: The model's discriminate ability was poor and predictive performance insufficient to classify women into relevant risk groups.

Original languageEnglish
Pages (from-to)265-276
Number of pages12
JournalHypertension in Pregnancy
Volume33
Issue number3
DOIs
Publication statusPublished - Aug 2014

Keywords

  • Early-onset
  • External validation
  • Prediction
  • Preeclampsia
  • Recurrence
  • LOW-PLASMA-VOLUME
  • HYPERTENSIVE DISORDER
  • 1ST PREGNANCY
  • RISK
  • WOMEN
  • DIAGNOSIS
  • DELIVERY
  • COHORT

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