Expression of tenascin in perifollicular connective tissue: comparison of normal scalp and alopecia areata

H M van Baar; C M Perret; I M van Vlijmen-Willems; J P Cleutjens; E J Mackie; R Happle; J Schalkwijk

doi:10.1007/BF00371614

Expression of tenascin in perifollicular connective tissue: comparison of normal scalp and alopecia areata

H M van Baar^*
, C M Perret
, I M van Vlijmen-Willems
, J P Cleutjens
, E J Mackie
, R Happle
, J Schalkwijk

^*Corresponding author for this work

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Abstract

Tenascin, a recently discovered extracellular matrix protein, was demonstrated in perifollicular connective tissue of normal human scalp using immunohistochemistry. Its localization was different from other well-known extracellular matrix components, like fibronectin, laminin and heparan sulphate proteoglycan. A comparison between alopecia areata and normal scalps did not reveal major qualitative differences, except for an increased expression near heavily infiltrated follicles.

Original language	English
Pages (from-to)	86-90
Number of pages	5
Journal	Archives of Dermatological Research
Volume	283
Issue number	2
DOIs	https://doi.org/10.1007/BF00371614
Publication status	Published - 1991

Keywords

Alopecia Areata/metabolism
Cell Adhesion Molecules, Neuronal/metabolism
Connective Tissue/metabolism
Extracellular Matrix Proteins/metabolism
Fibronectins/metabolism
Hair/cytology
Heparitin Sulfate/metabolism
Humans
Immunohistochemistry
Laminin/metabolism
Scalp/cytology
Tenascin

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10.1007/BF00371614

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title = "Expression of tenascin in perifollicular connective tissue: comparison of normal scalp and alopecia areata",

abstract = "Tenascin, a recently discovered extracellular matrix protein, was demonstrated in perifollicular connective tissue of normal human scalp using immunohistochemistry. Its localization was different from other well-known extracellular matrix components, like fibronectin, laminin and heparan sulphate proteoglycan. A comparison between alopecia areata and normal scalps did not reveal major qualitative differences, except for an increased expression near heavily infiltrated follicles.",

keywords = "Alopecia Areata/metabolism, Cell Adhesion Molecules, Neuronal/metabolism, Connective Tissue/metabolism, Extracellular Matrix Proteins/metabolism, Fibronectins/metabolism, Hair/cytology, Heparitin Sulfate/metabolism, Humans, Immunohistochemistry, Laminin/metabolism, Scalp/cytology, Tenascin",

author = "\{van Baar\}, \{H M\} and Perret, \{C M\} and \{van Vlijmen-Willems\}, \{I M\} and Cleutjens, \{J P\} and Mackie, \{E J\} and R Happle and J Schalkwijk",

year = "1991",

doi = "10.1007/BF00371614",

language = "English",

volume = "283",

pages = "86--90",

journal = "Archives of Dermatological Research",

issn = "0340-3696",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Expression of tenascin in perifollicular connective tissue

T2 - comparison of normal scalp and alopecia areata

AU - van Baar, H M

AU - Perret, C M

AU - van Vlijmen-Willems, I M

AU - Cleutjens, J P

AU - Mackie, E J

AU - Happle, R

AU - Schalkwijk, J

PY - 1991

Y1 - 1991

N2 - Tenascin, a recently discovered extracellular matrix protein, was demonstrated in perifollicular connective tissue of normal human scalp using immunohistochemistry. Its localization was different from other well-known extracellular matrix components, like fibronectin, laminin and heparan sulphate proteoglycan. A comparison between alopecia areata and normal scalps did not reveal major qualitative differences, except for an increased expression near heavily infiltrated follicles.

AB - Tenascin, a recently discovered extracellular matrix protein, was demonstrated in perifollicular connective tissue of normal human scalp using immunohistochemistry. Its localization was different from other well-known extracellular matrix components, like fibronectin, laminin and heparan sulphate proteoglycan. A comparison between alopecia areata and normal scalps did not reveal major qualitative differences, except for an increased expression near heavily infiltrated follicles.

KW - Alopecia Areata/metabolism

KW - Cell Adhesion Molecules, Neuronal/metabolism

KW - Connective Tissue/metabolism

KW - Extracellular Matrix Proteins/metabolism

KW - Fibronectins/metabolism

KW - Hair/cytology

KW - Heparitin Sulfate/metabolism

KW - Humans

KW - Immunohistochemistry

KW - Laminin/metabolism

KW - Scalp/cytology

KW - Tenascin

U2 - 10.1007/BF00371614

DO - 10.1007/BF00371614

M3 - Article

C2 - 1712578

SN - 0340-3696

VL - 283

SP - 86

EP - 90

JO - Archives of Dermatological Research

JF - Archives of Dermatological Research

IS - 2

ER -

Expression of tenascin in perifollicular connective tissue: comparison of normal scalp and alopecia areata

Abstract

Keywords

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