Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK)

GENEPSO, EMBRACE, HEBON, Kees van Roozendaal

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To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations.Retrospective cohort study (GENE-RAD-RISK).Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands,1993 female carriers of BRCA1/2 mutations recruited in 2006-09.Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated cumulative breast dose, based on nominal estimates of organ dose and frequency of self reported diagnostic procedures. To correct for potential survival bias, the analysis excluded carriers who were diagnosed more than five years before completion of the study questionnaire.In carriers of BRCA1/2 mutations any exposure to diagnostic radiation before the age of 30 was associated with an increased risk of breast cancer (hazard ratio 1.90, 95% confidence interval 1.20 to 3.00), with a dose-response pattern. The risks by quarter of estimated cumulative dose
Original languageEnglish
Article numbere5660
Publication statusPublished - 6 Sept 2012

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