Exploring the Relationship Between Movement Disorders and Physical Activity in Patients With Schizophrenia: An Actigraphy Study

Lydia E. Pieters*, Jeroen Deenik, Diederik E. Tenback, Jasper van Oort, Peter N. van Harten

*Corresponding author for this work

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Abstract

Low physical activity (PA) and sedentary behavior (SB) are major contributors to mental health burden and increased somatic comorbidity and mortality in people with schizophrenia and related psychoses. Movement disorders are highly prevalent in schizophrenia populations and are related to impaired functioning and poor clinical outcome. However, the relationship between movement disorders and PA and SB has remained largely unexplored. Therefore, we aimed to examine the relationship between movement disorders (akathisia, dyskinesia, dystonia, and parkinsonism) and PA and SB in 216 patients with schizophrenia and related psychoses. Actigraphy, the St. Hans Rating Scale for extrapyramidal syndromes, and psychopathological ratings (PANSS-r) were applied. Data were analyzed using multiple linear regression, adjusting for sex, age, negative symptoms, and defined daily dose of prescribed antipsychotics. Parkinsonism was significantly associated with decreased PA (beta = -0.21, P < .01) and increased SB(beta = 0.26, P < .001). For dystonia, only the relationship with SB was significant (beta = 0.15, P < .05). Akathisia was associated with more PA (beta = 0.14, P < .05) and less SB (beta = -0.15, P < .05). For dyskinesia, the relationships were non-significant. In a prediction model, akathisia, dystonia, parkinsonism and age significantly predicted PA (F(5,209) = 16.6, P < .001, R-Adjusted( )2= 0.27) and SB (F(4,210) = 13.4, P < .001, R-Adjusted(2) = 0.19).These findings suggest that movement disorders, in particular parkinsonism, are associated with reduced PA and increased SB in patients with psychotic disorders. Future studies should take movement disorders into account when examining PA and SB, to establish the clinical value of movement disorders in activating people with psychotic disorders to improve their mental and somatic health.

Original languageEnglish
Pages (from-to)906-914
Number of pages9
JournalSchizophrenia Bulletin
Volume47
Issue number4
DOIs
Publication statusPublished - Jul 2021

Keywords

  • psychosis
  • extrapyramidal symptoms
  • parkins onism
  • sedentary
  • behavior
  • somatic health
  • SEVERE MENTAL-ILLNESS
  • ANTIPSYCHOTIC-NAIVE PATIENTS
  • NEGATIVE SYNDROME SCALE
  • QUALITY-OF-LIFE
  • SEDENTARY BEHAVIOR
  • MOTOR ABNORMALITIES
  • REMISSION CRITERIA
  • HIGH-RISK
  • ASSOCIATION
  • RELIABILITY

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