Exploring the Electrophysiologic and Hemodynamic Effects of Cardiac Resynchronization Therapy: From Bench to Bedside and Vice Versa

Rick Schreurs, Rob F Wiegerinck, Frits W Prinzen

Research output: Contribution to journalArticleAcademicpeer-review


Cardiac resynchronization therapy (CRT) is an important therapy for heart failure patients with prolonged QRS duration. In patients with left bundle branch block the altered left ventricular electrical activation results in dyssynchronous, inefficient contraction of the left ventricle. CRT aims to reverse these changes and to improve cardiac function. This article explores the electrophysiologic and hemodynamic changes that occur during CRT in patient and animal studies. It also addresses how novel techniques, such as multipoint and endocardial pacing, can further improve the electromechanical response.

Original languageEnglish
Pages (from-to)599-608
Number of pages10
JournalCardiac Electrophysiology Clinics
Issue number4
Publication statusPublished - Dec 2015


  • Animals
  • Bundle-Branch Block
  • Cardiac Resynchronization Therapy
  • Excitation Contraction Coupling
  • Heart Conduction System
  • Heart Failure
  • Models, Cardiovascular
  • Myocardial Contraction
  • Translational Medical Research
  • Treatment Outcome
  • Ventricular Dysfunction, Left

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