Exploring the Electrophysiologic and Hemodynamic Effects of Cardiac Resynchronization Therapy: From Bench to Bedside and Vice Versa

Rick Schreurs, Rob F. Wiegerinck, Frits W. Prinzen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Cardiac resynchronization therapy (CRT) is an important therapy for heart failure patients with prolonged QRS duration. In patients with left bundle branch block the altered left ventricular electrical activation results in dyssynchronous, inefficient contraction of the left ventricle. CRT aims to reverse these changes and to improve cardiac function. This article explores the electrophysiologic and hemodynamic changes that occur during CRT in patient and animal studies. It also addresses how novel techniques, such as multipoint and endocardial pacing, can further improve the electromechanical response.

Original languageEnglish
Pages (from-to)43-52
Number of pages12
JournalHeart Failure Clinics
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2017

Keywords

  • Left bundle branch block
  • Cardiac resynchronization therapy
  • Animal research
  • Electrophysiology
  • Hemodynamics
  • BUNDLE-BRANCH BLOCK
  • DYSSYNCHRONOUS CANINE HEARTS
  • VENTRICULAR LEAD PLACEMENT
  • PRESSURE-VOLUME LOOPS
  • RESYNCHRONISATION THERAPY
  • FAILING HEART
  • SCAR TISSUE
  • FAILURE
  • OPTIMIZATION
  • STIMULATION

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