Exploring available models to investigate the brain of the gut and its role in colorectal cancer

Simone Louise Schonkeren

Research output: ThesisDoctoral ThesisInternal

121 Downloads (Pure)

Abstract

The enteric nervous system, also referred to as ‘the brain of the gut’, is important for gut functioning. In recent years, it has become evident that neurons can influence cancer, but how the brain of the gut influences colorectal cancer has hardly been investigated. This thesis focussed on the brain of the gut and its role in the development and progression of colorectal cancer. In addition, available models to study the brain of the gut were evaluated, with a focus on validating and improving these models for biomedical research. This research shows that neurons in the gut can influence colorectal cancer by sending signals to colorectal cancer cells on the one hand, and by influencing the immune system on the other hand.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Melotte, Veerle, Supervisor
  • Boesmans, Werend, Co-Supervisor
Award date4 May 2023
Place of PublicationMaastricht
Publisher
Print ISBNs9789464197648
DOIs
Publication statusPublished - 2023

Keywords

  • enteric nervous system
  • colorectal cancer
  • brain of the gut
  • intestinal motility

Cite this