Abstract
Hypoxia, i.e. low blood oxygen levels, is a common feature of solid tumours. Hypoxia causes tumour cells to become even more malignant. It is also associated with a poor prognosis and problems occurring during cancer treatment. This dissertation evaluates two potential cancer treatments targeting tumour hypoxia in a preclinical setting. We show that new substances targeting CA-IX, a protein occurring in hypoxic tumour regions, have promising anti-cancer effects. We also studied a new potential drug called CP-506. This substance is activated specifically in hypoxic regions. We demonstrate that CP-506 is a promising new substance with characteristics favourable for future clinical use. Our results confirm that treatment targeting tumour hypoxia is an interesting and promising approach to cancer.
Original language | English |
---|---|
Awarding Institution |
|
Supervisors/Advisors |
|
Award date | 26 Jun 2018 |
Place of Publication | Maastricht |
Publisher | |
Print ISBNs | 9789462339781 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- cancer
- tumour
- hypoxia
- CA-IX
- CP-506
- hypoxia-activated prodrug