Exploiting tumor hypoxia for cancer treatment

Raymon Servatius Theodorus Niemans

Research output: ThesisDoctoral ThesisExternal prepared

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Abstract

Hypoxia, i.e. low blood oxygen levels, is a common feature of solid tumours. Hypoxia causes tumour cells to become even more malignant. It is also associated with a poor prognosis and problems occurring during cancer treatment. This dissertation evaluates two potential cancer treatments targeting tumour hypoxia in a preclinical setting. We show that new substances targeting CA-IX, a protein occurring in hypoxic tumour regions, have promising anti-cancer effects. We also studied a new potential drug called CP-506. This substance is activated specifically in hypoxic regions. We demonstrate that CP-506 is a promising new substance with characteristics favourable for future clinical use. Our results confirm that treatment targeting tumour hypoxia is an interesting and promising approach to cancer.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Lambin, Philippe, Supervisor
  • Dubois, Ludwig, Advisor
  • Yaromina, Ala, Advisor
Award date26 Jun 2018
Place of PublicationMaastricht
Publisher
Print ISBNs9789462339781
DOIs
Publication statusPublished - 2018

Keywords

  • cancer
  • tumour
  • hypoxia
  • CA-IX
  • CP-506
  • hypoxia-activated prodrug

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