Exploiting causal functional relationships in Bayesian network modelling for personalised healthcare

Marina Velikova*, Josien Terwisscha van Scheltinga, Peter J. F. Lucas, Marc Spaanderman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Web of Science)

Abstract

Bridging the gap between the theory of Bayesian networks and solving an actual problem is still a big challenge and this is in particular true for medical problems, where such a gap is clearly evident. We argue that Bayesian networks offer appropriate technology for the successful modelling of medical problems, including the personalisation of healthcare. Personalisation is an important aspect of remote disease management systems. It involves the forecasting of progression of a disease based on the interpretation of patient data by a disease model. A natural foundation for disease models is physiological knowledge, as such knowledge facilitates building clinically understandable models. This paper proposes ways to represent such knowledge as part of engineering principles employed in building clinically practical probabilistic models. The methodology has been used to construct a temporal Bayesian network model for preeclampsia - a pregnancy-related disorder. The model is the first of its kind and an integral part of a mobile home-monitoring system intended for use in daily pregnancy care. We conducted an evaluation study with actual patient data to obtain insight into the model's performance and suitability. The results obtained are encouraging and show the potential of exploiting physiological knowledge for personalised decision-support systems.
Original languageEnglish
Pages (from-to)59-73
JournalInternational Journal of Approximate Reasoning
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Temporal Bayesian networks
  • Causal independence models
  • Clinical decision support
  • Pregnancy disorders
  • eHealth
  • Home monitoring

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