Experimental Investigation of the 2D Ion Beam Profile Generated by an ESI Octopole-QMS System

Sarfaraz U. A. H. Syed, Gert B. Eijkel, Piet Kistemaker, Shane Ellis, Simon Maher, Donald F. Smith, Ron M. A. Heeren*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


In this paper, we have employed an ion imaging approach to investigate the behavior of ions exiting from a quadrupole mass spectrometer (QMS) system that employs a radio frequency octopole ion guide before the QMS. An in-vacuum active pixel detector (Timepix) is employed at the exit of the QMS to image the ion patterns. The detector assembly simultaneously records the ion impact position and number of ions per pixel in every measurement frame. The transmission characteristics of the ion beam exiting the QMS are studied using this imaging detector under different operating conditions. Experimental results confirm that the ion spatial distribution exiting the QMS is heavily influenced by ion injection conditions. Furthermore, ion images from Timepix measurements of protein standards demonstrate the capability to enhance the quality of the mass spectral information and provide a detailed insight in the spatial distribution of different charge states (and hence different m/z) ions exiting the QMS.
Original languageEnglish
Pages (from-to)1780-1787
JournalJournal of the American Society for Mass Spectrometry
Issue number10
Publication statusPublished - Oct 2014


  • Quadrupole
  • Imaging MS
  • Ion transmission
  • Active pixel detector


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