Experimental Approaches to Identify Selective Picomolar Inhibitors for Carbonic Anhydrase IX

J. Kazokaite-Adomaitiene*, H.M. Becker, J. Smirnoviene, L.J. Dubois, D. Matulis

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Original languageEnglish
Pages (from-to)3361-3384
Number of pages24
JournalCurrent Medicinal Chemistry
Volume28
Issue number17
DOIs
Publication statusPublished - 2021

Keywords

  • Drug development
  • organic chemistry
  • cancer
  • sulfonamide
  • thermal shift assay
  • isothermal titration calorimetry
  • CA IX
  • THERMAL SHIFT ASSAYS
  • INTRINSIC THERMODYNAMICS
  • CATALYTIC-PROPERTIES
  • DRUG DESIGN
  • CA-IX
  • 1-ANILINO-8-NAPHTHALENE SULFONATE
  • TRANSPORT ACTIVITY
  • ENZYME-INHIBITORS
  • BINDING-AFFINITY
  • CO2 PERMEABILITY

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