TY - JOUR
T1 - Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective study
AU - Robroeks, C.M.
AU - van Berkel, J.J.
AU - Jöbsis, Q.
AU - van Schooten, F.J.
AU - Dallinga, J.W.
AU - Wouters, E.F.
AU - Dompeling, E.D.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - The hypothesis was that prediction of asthma exacerbations in children is possible by profiles of exhaled volatile organic compounds (VOCs), a non-invasive measure of airway inflammation.To study: 1) whether VOCs in exhaled breath are able to predict asthma exacerbations, and: 2) the time course and chemical background of the most predictive VOCs.A prospective study was performed in 40 children with asthma during one year. At standard 2-month intervals, FeNO, VOC profiles in exhaled breath samples, lung function and symptoms were determined in a standardised way. VOC profiles were analysed by gas chromatography time-of-flight mass spectrometry (GC-TOF-MS).16 out of 40 children experienced an exacerbation. With support vector machine analysis, the most optimal model of baseline measurements versus exacerbation within patients was based on 6 VOCs (correct classification 96%, sensitivity 100%, specificity 93%). The model of baseline values of patients with compared to levels of patients without an exacerbation consisted of 7 VOCs (correct classification 91%, sensitivity 79%, specificity 100%). FeNO and lung function were not predictive for exacerbations.This study indicates that a combination of different exhaled VOCs is able to predict exacerbations of childhood asthma.
AB - The hypothesis was that prediction of asthma exacerbations in children is possible by profiles of exhaled volatile organic compounds (VOCs), a non-invasive measure of airway inflammation.To study: 1) whether VOCs in exhaled breath are able to predict asthma exacerbations, and: 2) the time course and chemical background of the most predictive VOCs.A prospective study was performed in 40 children with asthma during one year. At standard 2-month intervals, FeNO, VOC profiles in exhaled breath samples, lung function and symptoms were determined in a standardised way. VOC profiles were analysed by gas chromatography time-of-flight mass spectrometry (GC-TOF-MS).16 out of 40 children experienced an exacerbation. With support vector machine analysis, the most optimal model of baseline measurements versus exacerbation within patients was based on 6 VOCs (correct classification 96%, sensitivity 100%, specificity 93%). The model of baseline values of patients with compared to levels of patients without an exacerbation consisted of 7 VOCs (correct classification 91%, sensitivity 79%, specificity 100%). FeNO and lung function were not predictive for exacerbations.This study indicates that a combination of different exhaled VOCs is able to predict exacerbations of childhood asthma.
U2 - 10.1183/09031936.00010712
DO - 10.1183/09031936.00010712
M3 - Article
C2 - 23645402
SN - 0903-1936
VL - 42
SP - 98
EP - 106
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 1
ER -