Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective

Michiel A. G. E. Bannier; Philippe P. R. Rosias; Quirijn Jobsis; Edward Dompeling

doi:10.3389/fped.2019.00150

Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective

Michiel A. G. E. Bannier^*, Philippe P. R. Rosias, Quirijn Jobsis, Edward Dompeling

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization.

Original language	English
Article number	150
Number of pages	11
Journal	Frontiers in pediatrics
Volume	7
DOIs	https://doi.org/10.3389/fped.2019.00150
Publication status	Published - 25 Apr 2019

Keywords

asthma
wheeze
exhaled breath condensate
exhaled breath
children
VOLATILE ORGANIC-COMPOUNDS
INHALED CORTICOSTEROIDS
8-ISOPROSTANE LEVELS
AIRWAY INFLAMMATION
CHILDREN
BIOMARKERS
LEUKOTRIENE
SEVERITY
EFFICACY
MARKERS

Access to Document

10.3389/fped.2019.00150Licence: CC BY

Cite this

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title = "Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective",

abstract = "Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization.",

keywords = "asthma, wheeze, exhaled breath condensate, exhaled breath, children, VOLATILE ORGANIC-COMPOUNDS, INHALED CORTICOSTEROIDS, 8-ISOPROSTANE LEVELS, AIRWAY INFLAMMATION, CHILDREN, BIOMARKERS, LEUKOTRIENE, SEVERITY, EFFICACY, MARKERS",

author = "Bannier, {Michiel A. G. E.} and Rosias, {Philippe P. R.} and Quirijn Jobsis and Edward Dompeling",

year = "2019",

month = apr,

day = "25",

doi = "10.3389/fped.2019.00150",

language = "English",

volume = "7",

journal = "Frontiers in pediatrics",

issn = "2296-2360",

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T2 - A Review and Current Perspective

AU - Bannier, Michiel A. G. E.

AU - Rosias, Philippe P. R.

AU - Jobsis, Quirijn

AU - Dompeling, Edward

PY - 2019/4/25

Y1 - 2019/4/25

N2 - Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization.

AB - Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization.

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KW - wheeze

KW - exhaled breath condensate

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KW - children

KW - VOLATILE ORGANIC-COMPOUNDS

KW - INHALED CORTICOSTEROIDS

KW - 8-ISOPROSTANE LEVELS

KW - AIRWAY INFLAMMATION

KW - CHILDREN

KW - BIOMARKERS

KW - LEUKOTRIENE

KW - SEVERITY

KW - EFFICACY

KW - MARKERS

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