Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective

Michiel A. G. E. Bannier*, Philippe P. R. Rosias, Quirijn Jobsis, Edward Dompeling

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Citations (Web of Science)

Abstract

Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization.

Original languageEnglish
Article number150
Number of pages11
JournalFrontiers in pediatrics
Volume7
DOIs
Publication statusPublished - 25 Apr 2019

Keywords

  • asthma
  • wheeze
  • exhaled breath condensate
  • exhaled breath
  • children
  • VOLATILE ORGANIC-COMPOUNDS
  • INHALED CORTICOSTEROIDS
  • 8-ISOPROSTANE LEVELS
  • AIRWAY INFLAMMATION
  • CHILDREN
  • BIOMARKERS
  • LEUKOTRIENE
  • SEVERITY
  • EFFICACY
  • MARKERS

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