Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity

Rudi Stinkens, Bram Brouwers, Johan W. Jocken, Ellen E. Blaak, Marianna F. Teunissen-Beekman, Matthijs K. Hesselink, Marleen A. van Baak, Patrick Schrauwen, Gijs H. Goossens*

*Corresponding author for this work

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Abstract

Rodent studies have indicated that physical exercise may improve adipose tissue function. We investigated the effects of a 12-wk supervised, progressive exercise training program on adipocyte morphology and abdominal subcutaneous adipose tissue function in metabolically well-phenotyped subjects with obesity. Men with obesity (n = 21) participated in a 12-wk supervised, progressive, combined exercise training program consisting of aerobic exercise (30 min at 70% of maximal power output 2 times/wk) and resistance exercise (3 = 10 repetitions at 60% of 1 repeated maximum 1 time/wk), with adjustment of exercise intensity every 4 wk. At baseline and after intervention, abdominal subcutaneous adipose tissue biopsies were collected to determine 1) adipocyte morphology, 2) gene expression of markers for lipolysis, inflammation, browning, adipokines, and mitochondrial biogenesis/function, 3) protein expression of mitochondrial oxidative phosphorylation (OXPHOS) complexes, and 4) ex vivo basal and beta(2)-adrenergic stimulated lipolysis. The exercise training program, which increased maximal aerobic capacity (P

NEW & NOTEWORTHY Studies that investigated the effects of exercise training on adipose tissue function in well-phenotyped humans are scarce. We demonstrate that 12 wk of supervised exercise training improved physical fitness and peripheral insulin sensitivity but did not alter abdominal subcutaneous adipocyte morphology, adipose tissue gene and protein expression of markers related to adipose tissue function, or beta(2)-adrenergic receptor-mediated lipolysis in men with obesity. A prolonged and/or more intense training program may be required to improve human adipose tissue function.

Original languageEnglish
Pages (from-to)1585-1593
Number of pages9
JournalJournal of Applied Physiology
Volume125
Issue number5
DOIs
Publication statusPublished - Nov 2018

Keywords

  • abdominal subcutaneous adipose tissue
  • exercise training
  • gene expression
  • obesity
  • protein expression
  • IMPROVES INSULIN SENSITIVITY
  • GENE-EXPRESSION
  • MITOCHONDRIAL BIOGENESIS
  • OXIDATIVE CAPACITY
  • SKELETAL-MUSCLE
  • MESSENGER-RNA
  • PLASMA-LEVELS
  • WHITE FAT
  • BROWN
  • PGC-1-ALPHA

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