Exercise and training in NAFLD and insulin resistance: psychological approach in humans

Bram Brouwers

Research output: ThesisDoctoral ThesisInternal

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Worldwide, 415 million adults have been diagnosed with diabetes. When fatty liver is caused by something other than excessive alcohol use it is known as non-alcoholic fatty liver (NAFL), which is an important risk factor for diabetes. An estimated 20% of the global population has NAFL and a staggering 50% of obese people have the disease. NAFL is often symptom-free, which makes it an underdiagnosed condition for which no treatment currently exists. This dissertation found that men with NAFL have greatly reduced sugar sensitivity compared to diabetics. A twelve-week exercise and training programme improved sugar sensitivity and led to a sharp reduction in the amount of fat in the liver. First-line treatment to prevent diabetes should therefore be offered to people with NAFL.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Schrauwen, Patrick, Supervisor
  • Hesselink, Matthijs, Supervisor
  • Schrauwen - Hinderling, Vera, Co-Supervisor
Award date24 Jun 2016
Place of PublicationMaastricht
Publication statusPublished - 2016


  • diabetes
  • non-alcoholic fatty liver (NAFL)
  • prevention


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