Abstract
The interaction of an individual’s genetic background with adverse environmental experiences, aka gene × environment interaction, is one of the main pathogenic factors for neurodevelopmental disorders, such as attention-deficit/hyperactivity disorder and autism spectrum disorders, but not many models are available to mimic this situation experimentally. This thesis investigates the changes in aggression, anxiety, social behaviour, neurochemical, and molecular effects caused by different kinds of stress in two experimental genetic animal models and studies the validity of these models as models of gene × environment interaction in neurodevelopmental disorders.
Original language | English |
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Awarding Institution |
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Supervisors/Advisors |
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Award date | 11 Jan 2022 |
Place of Publication | Maastricht |
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Print ISBNs | 9785001665250 |
DOIs | |
Publication status | Published - 2022 |
Keywords
- aggression
- animal models
- ADHD
- ASD