Excessive adventitial stress drives inflammation-mediated fibrosis in hypertensive aortic remodelling in mice

B. Spronck*, M. Latorre, M. Wang, S. Mehta, A.W. Caulk, P.W. Ren, A.B. Ramachandra, S.I. Murtada, A. Rojas, C.S. He, B. Jiang, M.R. Bersi, G. Tellides, J.D. Humphrey*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number20210336
Number of pages11
JournalJournal of the Royal Society Interface
Volume18
Issue number180
DOIs
Publication statusPublished - 28 Jul 2021

Keywords

  • aorta
  • fibrosis
  • stiffness
  • inflammation
  • contractility
  • C57BL
  • 6 J
  • 129S6
  • SvEvTac
  • smooth muscle phenotype
  • SMOOTH-MUSCLE-CELLS
  • ANGIOTENSIN-II
  • ARTERIAL ADAPTATIONS
  • COLLAGEN-SYNTHESIS
  • AT(1) RECEPTOR
  • VASCULAR WALL
  • ACTIVATION
  • ACCUMULATION
  • HYPERTROPHY
  • INVOLVEMENT

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