Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study

Laura Fusar-Poli; Thanavadee Prachason; Gamze Erzin; Lotta-Katrin Pries; Natascia Brondino; Pierluigi Politi; Philippe Delespaul; Gunter Kenis; Jurjen J. Luykx; Bochao D. Lin; Alexander L. Richards; Berna Akdede; Tolga Binbay; Vesile Altinyazar; Berna Yalincetin; Guvem Gumus-Akay; Burcin Cihan; Haldun Soygur; Halis Ulas; Eylem Sahin Cankurtaran; Semra Ulusoy Kaymak; Marina M. Mihaljevic; Sanja Andric-Petrovic; Tijana Mirjanic; Miguel Bernardo; Gisela Mezquida; Silvia Amoretti; Julio Bobes; Pilar A. Saiz; Maria Paz Garcia-Portilla; Julio Sanjuan; Maria Jose Escarti; Jose Luis Santos; Estela Jimenez-Lopez; Manuel Arrojo; Angel Carracedo; Gonzalo Lopez; Javier Gonzalez-Penas; Mara Parellada; Nadja P. Maric; Cem Atbasoglu; Alp Ucok; Koksal Alptekin; Meram Can Saka; Celso Arango; Michael O'Donovan; Jim van Os; Bart P. F. Rutten; Sinan Guloksuz; Genetic Risk and Outcome of Psychosis (GROUP) Investigators

doi:10.1016/j.psychres.2023.115184

Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study

Laura Fusar-Poli, Thanavadee Prachason, Gamze Erzin, Lotta-Katrin Pries, Natascia Brondino, Pierluigi Politi, Philippe Delespaul, Gunter Kenis, Jurjen J. Luykx, Bochao D. Lin, Alexander L. Richards, Berna Akdede, Tolga Binbay, Vesile Altinyazar, Berna Yalincetin, Guvem Gumus-Akay, Burcin Cihan, Haldun Soygur, Halis Ulas, Eylem Sahin CankurtaranSemra Ulusoy Kaymak, Marina M. Mihaljevic, Sanja Andric-Petrovic, Tijana Mirjanic, Miguel Bernardo, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A. Saiz, Maria Paz Garcia-Portilla, Julio Sanjuan, Maria Jose Escarti, Jose Luis Santos, Estela Jimenez-Lopez, Manuel Arrojo, Angel Carracedo, Gonzalo Lopez, Javier Gonzalez-Penas, Mara Parellada, Nadja P. Maric, Cem Atbasoglu, Alp Ucok, Koksal Alptekin, Meram Can Saka, Celso Arango, Michael O'Donovan, Jim van Os, Bart P. F. Rutten, Sinan Guloksuz^*, Genetic Risk and Outcome of Psychosis (GROUP) Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) -a cumulative environmental exposure score -was associated with impairments of neurocognition, social cognition, and perception in patients with SSD, their unaffected siblings, and healthy controls. Methods: This cross-sectional sample consisted of 1200 patients, 1371 siblings, and 1564 healthy controls. Neurocognition, social cognition, and perception were assesed using a short version of the Wechsler Adult In-telligence Scale-Third Edition (WAIS-III), the Degraded Facial Affect Recognition Task (DFAR), and the Benton Facial Recognition Test (BFR), respectively. Regression models were used to analyze the association between ES-SCZ and cognitive domains in each group.Results: There were no statistically significant associations between ES-SCZ and cognitive domains in SSD. ES-SCZ was negatively associated with T-score of cognition in siblings (B=-0.40, 95% CI-0.76 to-0.03) and healthy controls (B=-0.63, 95% CI-1.06 to-0.21). Additionally, ES-SCZ was positively associated with DFAR-total in siblings (B=0.83, 95% CI 0.26 to 1.40). Sensitivity analyses excluding cannabis use history from ES-SCZ largely confirmed the main findings.Conclusions: Longitudinal cohorts may elucidate how environmental exposures influence the onset and course of cognitive impairments in trans-syndromic psychosis spectrum.

Original language	English
Article number	115184
Number of pages	10
Journal	Psychiatry Research
Volume	323
Issue number	1
Early online date	1 Apr 2023
DOIs	https://doi.org/10.1016/j.psychres.2023.115184
Publication status	Published - 1 May 2023

Keywords

Psychosis
Cannabis use
Childhood trauma
Environment
Emotion recognition
GENE-ENVIRONMENT INTERACTIONS
CHILDHOOD TRAUMA
SHORT-FORM
PSYCHOSIS
RISK
RELIABILITY
PERFORMANCE
VALIDATION
INSTRUMENT
OVERLAP

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Fusar-Poli, L., Prachason, T., Erzin, G., Pries, L.-K., Brondino, N., Politi, P., Delespaul, P., Kenis, G., Luykx, J. J., Lin, B. D., Richards, A. L., Akdede, B., Binbay, T., Altinyazar, V., Yalincetin, B., Gumus-Akay, G., Cihan, B., Soygur, H., Ulas, H., ... Genetic Risk and Outcome of Psychosis (GROUP) Investigators (2023). Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. Psychiatry Research, 323(1), Article 115184. https://doi.org/10.1016/j.psychres.2023.115184

@article{3eb18915110c4b0bb58d53424f740b97,

title = "Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study",

abstract = "Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) -a cumulative environmental exposure score -was associated with impairments of neurocognition, social cognition, and perception in patients with SSD, their unaffected siblings, and healthy controls. Methods: This cross-sectional sample consisted of 1200 patients, 1371 siblings, and 1564 healthy controls. Neurocognition, social cognition, and perception were assesed using a short version of the Wechsler Adult In-telligence Scale-Third Edition (WAIS-III), the Degraded Facial Affect Recognition Task (DFAR), and the Benton Facial Recognition Test (BFR), respectively. Regression models were used to analyze the association between ES-SCZ and cognitive domains in each group.Results: There were no statistically significant associations between ES-SCZ and cognitive domains in SSD. ES-SCZ was negatively associated with T-score of cognition in siblings (B=-0.40, 95% CI-0.76 to-0.03) and healthy controls (B=-0.63, 95% CI-1.06 to-0.21). Additionally, ES-SCZ was positively associated with DFAR-total in siblings (B=0.83, 95% CI 0.26 to 1.40). Sensitivity analyses excluding cannabis use history from ES-SCZ largely confirmed the main findings.Conclusions: Longitudinal cohorts may elucidate how environmental exposures influence the onset and course of cognitive impairments in trans-syndromic psychosis spectrum.",

keywords = "Psychosis, Cannabis use, Childhood trauma, Environment, Emotion recognition, GENE-ENVIRONMENT INTERACTIONS, CHILDHOOD TRAUMA, SHORT-FORM, PSYCHOSIS, RISK, RELIABILITY, PERFORMANCE, VALIDATION, INSTRUMENT, OVERLAP",

author = "Laura Fusar-Poli and Thanavadee Prachason and Gamze Erzin and Lotta-Katrin Pries and Natascia Brondino and Pierluigi Politi and Philippe Delespaul and Gunter Kenis and Luykx, {Jurjen J.} and Lin, {Bochao D.} and Richards, {Alexander L.} and Berna Akdede and Tolga Binbay and Vesile Altinyazar and Berna Yalincetin and Guvem Gumus-Akay and Burcin Cihan and Haldun Soygur and Halis Ulas and Cankurtaran, {Eylem Sahin} and Kaymak, {Semra Ulusoy} and Mihaljevic, {Marina M.} and Sanja Andric-Petrovic and Tijana Mirjanic and Miguel Bernardo and Gisela Mezquida and Silvia Amoretti and Julio Bobes and Saiz, {Pilar A.} and Garcia-Portilla, {Maria Paz} and Julio Sanjuan and Escarti, {Maria Jose} and Santos, {Jose Luis} and Estela Jimenez-Lopez and Manuel Arrojo and Angel Carracedo and Gonzalo Lopez and Javier Gonzalez-Penas and Mara Parellada and Maric, {Nadja P.} and Cem Atbasoglu and Alp Ucok and Koksal Alptekin and Saka, {Meram Can} and Celso Arango and Michael O'Donovan and {van Os}, Jim and Rutten, {Bart P. F.} and Sinan Guloksuz and {Genetic Risk and Outcome of Psychosis (GROUP) Investigators}",

year = "2023",

month = may,

day = "1",

doi = "10.1016/j.psychres.2023.115184",

language = "English",

volume = "323",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

Fusar-Poli, L, Prachason, T, Erzin, G, Pries, L-K, Brondino, N, Politi, P, Delespaul, P , Kenis, G, Luykx, JJ, Lin, BD, Richards, AL, Akdede, B, Binbay, T, Altinyazar, V, Yalincetin, B, Gumus-Akay, G, Cihan, B, Soygur, H, Ulas, H, Cankurtaran, ES, Kaymak, SU, Mihaljevic, MM, Andric-Petrovic, S, Mirjanic, T, Bernardo, M, Mezquida, G, Amoretti, S, Bobes, J, Saiz, PA, Garcia-Portilla, MP, Sanjuan, J, Escarti, MJ, Santos, JL, Jimenez-Lopez, E, Arrojo, M, Carracedo, A, Lopez, G, Gonzalez-Penas, J, Parellada, M, Maric, NP, Atbasoglu, C, Ucok, A, Alptekin, K, Saka, MC, Arango, C, O'Donovan, M, van Os, J, Rutten, BPF , Guloksuz, S & Genetic Risk and Outcome of Psychosis (GROUP) Investigators 2023, 'Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study', Psychiatry Research, vol. 323, no. 1, 115184. https://doi.org/10.1016/j.psychres.2023.115184

TY - JOUR

T1 - Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls

T2 - Results from the EUGEI study

AU - Fusar-Poli, Laura

AU - Prachason, Thanavadee

AU - Erzin, Gamze

AU - Pries, Lotta-Katrin

AU - Brondino, Natascia

AU - Politi, Pierluigi

AU - Delespaul, Philippe

AU - Kenis, Gunter

AU - Luykx, Jurjen J.

AU - Lin, Bochao D.

AU - Richards, Alexander L.

AU - Akdede, Berna

AU - Binbay, Tolga

AU - Altinyazar, Vesile

AU - Yalincetin, Berna

AU - Gumus-Akay, Guvem

AU - Cihan, Burcin

AU - Soygur, Haldun

AU - Ulas, Halis

AU - Cankurtaran, Eylem Sahin

AU - Kaymak, Semra Ulusoy

AU - Mihaljevic, Marina M.

AU - Andric-Petrovic, Sanja

AU - Mirjanic, Tijana

AU - Bernardo, Miguel

AU - Mezquida, Gisela

AU - Amoretti, Silvia

AU - Bobes, Julio

AU - Saiz, Pilar A.

AU - Garcia-Portilla, Maria Paz

AU - Sanjuan, Julio

AU - Escarti, Maria Jose

AU - Santos, Jose Luis

AU - Jimenez-Lopez, Estela

AU - Arrojo, Manuel

AU - Carracedo, Angel

AU - Lopez, Gonzalo

AU - Gonzalez-Penas, Javier

AU - Parellada, Mara

AU - Maric, Nadja P.

AU - Atbasoglu, Cem

AU - Ucok, Alp

AU - Alptekin, Koksal

AU - Saka, Meram Can

AU - Arango, Celso

AU - O'Donovan, Michael

AU - van Os, Jim

AU - Rutten, Bart P. F.

AU - Guloksuz, Sinan

AU - Genetic Risk and Outcome of Psychosis (GROUP) Investigators

PY - 2023/5/1

Y1 - 2023/5/1

N2 - Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) -a cumulative environmental exposure score -was associated with impairments of neurocognition, social cognition, and perception in patients with SSD, their unaffected siblings, and healthy controls. Methods: This cross-sectional sample consisted of 1200 patients, 1371 siblings, and 1564 healthy controls. Neurocognition, social cognition, and perception were assesed using a short version of the Wechsler Adult In-telligence Scale-Third Edition (WAIS-III), the Degraded Facial Affect Recognition Task (DFAR), and the Benton Facial Recognition Test (BFR), respectively. Regression models were used to analyze the association between ES-SCZ and cognitive domains in each group.Results: There were no statistically significant associations between ES-SCZ and cognitive domains in SSD. ES-SCZ was negatively associated with T-score of cognition in siblings (B=-0.40, 95% CI-0.76 to-0.03) and healthy controls (B=-0.63, 95% CI-1.06 to-0.21). Additionally, ES-SCZ was positively associated with DFAR-total in siblings (B=0.83, 95% CI 0.26 to 1.40). Sensitivity analyses excluding cannabis use history from ES-SCZ largely confirmed the main findings.Conclusions: Longitudinal cohorts may elucidate how environmental exposures influence the onset and course of cognitive impairments in trans-syndromic psychosis spectrum.

AB - Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) -a cumulative environmental exposure score -was associated with impairments of neurocognition, social cognition, and perception in patients with SSD, their unaffected siblings, and healthy controls. Methods: This cross-sectional sample consisted of 1200 patients, 1371 siblings, and 1564 healthy controls. Neurocognition, social cognition, and perception were assesed using a short version of the Wechsler Adult In-telligence Scale-Third Edition (WAIS-III), the Degraded Facial Affect Recognition Task (DFAR), and the Benton Facial Recognition Test (BFR), respectively. Regression models were used to analyze the association between ES-SCZ and cognitive domains in each group.Results: There were no statistically significant associations between ES-SCZ and cognitive domains in SSD. ES-SCZ was negatively associated with T-score of cognition in siblings (B=-0.40, 95% CI-0.76 to-0.03) and healthy controls (B=-0.63, 95% CI-1.06 to-0.21). Additionally, ES-SCZ was positively associated with DFAR-total in siblings (B=0.83, 95% CI 0.26 to 1.40). Sensitivity analyses excluding cannabis use history from ES-SCZ largely confirmed the main findings.Conclusions: Longitudinal cohorts may elucidate how environmental exposures influence the onset and course of cognitive impairments in trans-syndromic psychosis spectrum.

KW - Psychosis

KW - Cannabis use

KW - Childhood trauma

KW - Environment

KW - Emotion recognition

KW - GENE-ENVIRONMENT INTERACTIONS

KW - CHILDHOOD TRAUMA

KW - SHORT-FORM

KW - PSYCHOSIS

KW - RISK

KW - RELIABILITY

KW - PERFORMANCE

KW - VALIDATION

KW - INSTRUMENT

KW - OVERLAP

U2 - 10.1016/j.psychres.2023.115184

DO - 10.1016/j.psychres.2023.115184

M3 - Article

C2 - 37015164

SN - 0165-1781

VL - 323

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1

M1 - 115184

ER -

Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study

Abstract

Keywords

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