EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors

Jos Prickaerts; Nick P. van Goethem; Richard Chesworth; Gideon Shapiro; Frank G. Boess; Christoph Methfessel; Olga A. H. Reneerkens; Dorothy G. Flood; Dana Hilt; Maria Gawryl; Sonia Bertrand; Daniel Bertrand; Gerhard Koenig

doi:10.1016/j.neuropharm.2011.10.024

EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors

Jos Prickaerts, Nick P. van Goethem, Richard Chesworth, Gideon Shapiro, Frank G. Boess, Christoph Methfessel, Olga A. H. Reneerkens, Dorothy G. Flood, Dana Hilt, Maria Gawryl, Sonia Bertrand, Daniel Bertrand, Gerhard Koenig

MHeNs School for Mental Health and Neuroscience

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1099-1110
Journal	Neuropharmacology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/j.neuropharm.2011.10.024
Publication status	Published - Feb 2012

Keywords

alpha 7 nAChR
Object recognition task
Memory
Partial agonist
Novel mechanism of action
Acetylcholine esterase inhibitor

Access to Document

10.1016/j.neuropharm.2011.10.024

Cite this

Prickaerts, J., van Goethem, N. P., Chesworth, R., Shapiro, G., Boess, F. G., Methfessel, C., Reneerkens, O. A. H., Flood, D. G., Hilt, D., Gawryl, M., Bertrand, S., Bertrand, D., & Koenig, G. (2012). EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors. Neuropharmacology, 62(2), 1099-1110. https://doi.org/10.1016/j.neuropharm.2011.10.024

Prickaerts, Jos ; van Goethem, Nick P. ; Chesworth, Richard ; Shapiro, Gideon ; Boess, Frank G. ; Methfessel, Christoph ; Reneerkens, Olga A. H. ; Flood, Dorothy G. ; Hilt, Dana ; Gawryl, Maria ; Bertrand, Sonia ; Bertrand, Daniel ; Koenig, Gerhard. / EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors. In: Neuropharmacology. 2012 ; Vol. 62, No. 2. pp. 1099-1110.

@article{c57ffdfa863a4c52ae7dd23a3c51271e,

title = "EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors",

keywords = "alpha 7 nAChR, Object recognition task, Memory, Partial agonist, Novel mechanism of action, Acetylcholine esterase inhibitor",

author = "Jos Prickaerts and {van Goethem}, {Nick P.} and Richard Chesworth and Gideon Shapiro and Boess, {Frank G.} and Christoph Methfessel and Reneerkens, {Olga A. H.} and Flood, {Dorothy G.} and Dana Hilt and Maria Gawryl and Sonia Bertrand and Daniel Bertrand and Gerhard Koenig",

year = "2012",

month = feb,

doi = "10.1016/j.neuropharm.2011.10.024",

language = "English",

volume = "62",

pages = "1099--1110",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Science",

number = "2",

}

Prickaerts, J, van Goethem, NP, Chesworth, R, Shapiro, G, Boess, FG, Methfessel, C, Reneerkens, OAH, Flood, DG, Hilt, D, Gawryl, M, Bertrand, S, Bertrand, D & Koenig, G 2012, 'EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors', Neuropharmacology, vol. 62, no. 2, pp. 1099-1110. https://doi.org/10.1016/j.neuropharm.2011.10.024

EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors. / Prickaerts, Jos; van Goethem, Nick P.; Chesworth, Richard; Shapiro, Gideon; Boess, Frank G.; Methfessel, Christoph; Reneerkens, Olga A. H.; Flood, Dorothy G.; Hilt, Dana; Gawryl, Maria; Bertrand, Sonia; Bertrand, Daniel; Koenig, Gerhard.

In: Neuropharmacology, Vol. 62, No. 2, 02.2012, p. 1099-1110.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors

AU - Prickaerts, Jos

AU - van Goethem, Nick P.

AU - Chesworth, Richard

AU - Shapiro, Gideon

AU - Boess, Frank G.

AU - Methfessel, Christoph

AU - Reneerkens, Olga A. H.

AU - Flood, Dorothy G.

AU - Hilt, Dana

AU - Gawryl, Maria

AU - Bertrand, Sonia

AU - Bertrand, Daniel

AU - Koenig, Gerhard

PY - 2012/2

Y1 - 2012/2

KW - alpha 7 nAChR

KW - Object recognition task

KW - Memory

KW - Partial agonist

KW - Novel mechanism of action

KW - Acetylcholine esterase inhibitor

U2 - 10.1016/j.neuropharm.2011.10.024

DO - 10.1016/j.neuropharm.2011.10.024

M3 - Article

VL - 62

SP - 1099

EP - 1110

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 2

ER -

Prickaerts J, van Goethem NP, Chesworth R, Shapiro G, Boess FG, Methfessel C et al. EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors. Neuropharmacology. 2012 Feb;62(2):1099-1110. https://doi.org/10.1016/j.neuropharm.2011.10.024