TY - JOUR
T1 - Evoked delayed potential ablation for post-myocardial infarction ventricular tachycardia
T2 - results from a large prospective multicentre study
AU - de Riva, Marta
AU - Evertz, Reinder
AU - Lukac, Peter
AU - Dekker, Lukas R. C.
AU - Blaauw, Yuri
AU - ter Bekke, Rachel M. A.
AU - Kimura, Yoshitaka
AU - Beukema, Rypko J.
AU - Ouss, Alexandre
AU - Mulder, Bart A.
AU - Vernooy, Kevin
AU - Wijnmaalen, Adrianus P.
AU - Zeppenfeld, Katja
PY - 2025/2/24
Y1 - 2025/2/24
N2 - Aims The optimal substrate ablation approach for post-myocardial infarction (MI) ventricular tachycardia (VT) is unknown. Proposed ablation targets are prone to individual interpretation making the ablation outcome potentially operator dependent. Evoked delayed potentials (EDPs) are a well-defined target. Evoked delayed potential ablation was effective in preventing post-MI VT recurrence in a prior study. The aims of this study were to assess long-term outcomes of EDP ablation in a large multicentre cohort of post-MI patients and to compare ablation outcomes between centres with and without prior experience in EDP ablation.Methods and results Patients with post-MI VT undergoing ablation in one centre performing EDP ablation since 2013 and five centres without prior experience in EDP ablation were prospectively included. A uniform mapping protocol including right ventricular extra-stimulation aiming to EDP identification was followed. Ablation endpoints were EDP elimination and VT non-inducibility. Patients were followed for VT recurrence, mortality, heart transplant, and left ventricular assist device implantation. In total, 130 patients were included. The protocol was successfully performed in 99%, and in 94%, EDPs were identified and ablated. In total, 78% of patients were rendered non-inducible. Ventricular tachycardia-free survival was 78% [95% confidence interval (CI) 71-85] and 71% (95% CI 63-80) at 6 and 12 months, respectively. No difference in VT-free survival was observed among centres with and without prior experience in EPD ablation.Conclusion In a large multicentre prospective cohort of patients with post-MI VT, EDP ablation resulted in good long-term outcomes. Importantly, VT recurrence rates did not differ among centres with and without prior experience in EDP ablation, indicating that this approach can be easily reproduced by operators previously not familiar with the technique.
AB - Aims The optimal substrate ablation approach for post-myocardial infarction (MI) ventricular tachycardia (VT) is unknown. Proposed ablation targets are prone to individual interpretation making the ablation outcome potentially operator dependent. Evoked delayed potentials (EDPs) are a well-defined target. Evoked delayed potential ablation was effective in preventing post-MI VT recurrence in a prior study. The aims of this study were to assess long-term outcomes of EDP ablation in a large multicentre cohort of post-MI patients and to compare ablation outcomes between centres with and without prior experience in EDP ablation.Methods and results Patients with post-MI VT undergoing ablation in one centre performing EDP ablation since 2013 and five centres without prior experience in EDP ablation were prospectively included. A uniform mapping protocol including right ventricular extra-stimulation aiming to EDP identification was followed. Ablation endpoints were EDP elimination and VT non-inducibility. Patients were followed for VT recurrence, mortality, heart transplant, and left ventricular assist device implantation. In total, 130 patients were included. The protocol was successfully performed in 99%, and in 94%, EDPs were identified and ablated. In total, 78% of patients were rendered non-inducible. Ventricular tachycardia-free survival was 78% [95% confidence interval (CI) 71-85] and 71% (95% CI 63-80) at 6 and 12 months, respectively. No difference in VT-free survival was observed among centres with and without prior experience in EPD ablation.Conclusion In a large multicentre prospective cohort of patients with post-MI VT, EDP ablation resulted in good long-term outcomes. Importantly, VT recurrence rates did not differ among centres with and without prior experience in EDP ablation, indicating that this approach can be easily reproduced by operators previously not familiar with the technique.
KW - Ventricular tachycardia
KW - Myocardial infarction
KW - Substrate ablation
KW - Substrate modification
KW - Functional substrate mapping
KW - Evoked delayed potentials
KW - SUBSTRATE ABLATION
KW - END-POINT
KW - CATHETER ABLATION
KW - NONINDUCIBILITY
KW - SAFETY
U2 - 10.1093/europace/euaf003
DO - 10.1093/europace/euaf003
M3 - Article
SN - 1099-5129
VL - 27
JO - EP Europace
JF - EP Europace
IS - 2
M1 - euaf003
ER -