TY - JOUR
T1 - Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress
AU - Behan, Aine T.
AU - Van den Hove, Daniel L. A.
AU - Mueller, Lynn
AU - Jetten, Marlon J. A.
AU - Steinbusch, Harry W. M.
AU - Cotter, David R.
AU - Prickaerts, Jos
PY - 2011/1
Y1 - 2011/1
N2 - Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.
AB - Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.
KW - Prenatal stress
KW - Mice
KW - Hippocampus
KW - Sexual dimorphism
KW - Psychiatric disorders
U2 - 10.1016/j.euroneuro.2010.07.004
DO - 10.1016/j.euroneuro.2010.07.004
M3 - Article
C2 - 20702067
SN - 0924-977X
VL - 21
SP - 71
EP - 79
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 1
ER -