Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress

Aine T. Behan*, Daniel L. A. Van den Hove, Lynn Mueller, Marlon J. A. Jetten, Harry W. M. Steinbusch, David R. Cotter, Jos Prickaerts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Web of Science)


Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.
Original languageEnglish
Pages (from-to)71-79
JournalEuropean Neuropsychopharmacology
Issue number1
Publication statusPublished - Jan 2011


  • Prenatal stress
  • Mice
  • Hippocampus
  • Sexual dimorphism
  • Psychiatric disorders

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