Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta-analysis on HPV, p16, and TP53

Frans J. Mulder; Damiana D. C. G. Pierssens; Laura W. J. Baijens; Bernd Kremer; Ernst-Jan M. Speel

doi:10.1002/hed.26513

Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta-analysis on HPV, p16, and TP53

Frans J. Mulder^*, Damiana D. C. G. Pierssens, Laura W. J. Baijens, Bernd Kremer, Ernst-Jan M. Speel

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Background The goal of this review was to present an overview of the currently identified molecular parameters in head and neck squamous cell carcinoma (HNSCC) of nonsmokers and nondrinkers (NSND).

Methods Following the PRISMA guidelines, a systematic search was performed using the electronic databases PubMed, Embase, and Google Scholar.

Results Of the 902 analyzed unique studies, 74 were included in a quantitative synthesis and 24 in a meta-analysis. Human papillomavirus (HPV) was reported as a molecular parameter in 38 studies, followed by p16 and TP53 (23 and 14 studies, respectively). The variety of other molecular parameters concerned sporadic findings in small numbers of NSND.

Conclusions HNSCC in NSND is more often related to HPV and p16 overexpression compared to tumors of smokers-drinkers. In a third of virus-negative tumors, TP53 mutations were detected with a mutational profile associated with aging and ultraviolet light exposure rather than to tobacco consumption.

Original language	English
Pages (from-to)	303-322
Number of pages	20
Journal	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume	43
Issue number	1
Early online date	23 Oct 2020
DOIs	https://doi.org/10.1002/hed.26513
Publication status	Published - Jan 2021

Keywords

head and neck cancer
human papillomavirus
nonsmokers
p16
TP53
HUMAN-PAPILLOMAVIRUS INFECTION
NON-DRINKING PATIENTS
ORAL TONGUE
OROPHARYNGEAL CANCER
P53 EXPRESSION
TOBACCO SMOKING
NEVER-DRINKERS
RISK-FACTORS
CLINICOPATHOLOGICAL CHARACTERISTICS
PROGNOSTIC BIOMARKERS

Access to Document

10.1002/hed.26513Licence: CC BY

Cite this

Mulder, F. J., Pierssens, D. D. C. G., Baijens, L. W. J., Kremer, B., & Speel, E.-J. M. (2021). Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta-analysis on HPV, p16, and TP53. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 43(1), 303-322. https://doi.org/10.1002/hed.26513

Mulder, Frans J. ; Pierssens, Damiana D. C. G. ; Baijens, Laura W. J. et al. / Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers : Systematic review and meta-analysis on HPV, p16, and TP53. In: Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 2021 ; Vol. 43, No. 1. pp. 303-322.

@article{d1438b2ee8ab4a2b8fc69769bf97a6f4,

title = "Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta-analysis on HPV, p16, and TP53",

abstract = "Background The goal of this review was to present an overview of the currently identified molecular parameters in head and neck squamous cell carcinoma (HNSCC) of nonsmokers and nondrinkers (NSND).Methods Following the PRISMA guidelines, a systematic search was performed using the electronic databases PubMed, Embase, and Google Scholar.Results Of the 902 analyzed unique studies, 74 were included in a quantitative synthesis and 24 in a meta-analysis. Human papillomavirus (HPV) was reported as a molecular parameter in 38 studies, followed by p16 and TP53 (23 and 14 studies, respectively). The variety of other molecular parameters concerned sporadic findings in small numbers of NSND.Conclusions HNSCC in NSND is more often related to HPV and p16 overexpression compared to tumors of smokers-drinkers. In a third of virus-negative tumors, TP53 mutations were detected with a mutational profile associated with aging and ultraviolet light exposure rather than to tobacco consumption.",

keywords = "head and neck cancer, human papillomavirus, nonsmokers, p16, TP53, HUMAN-PAPILLOMAVIRUS INFECTION, NON-DRINKING PATIENTS, ORAL TONGUE, OROPHARYNGEAL CANCER, P53 EXPRESSION, TOBACCO SMOKING, NEVER-DRINKERS, RISK-FACTORS, CLINICOPATHOLOGICAL CHARACTERISTICS, PROGNOSTIC BIOMARKERS",

author = "Mulder, {Frans J.} and Pierssens, {Damiana D. C. G.} and Baijens, {Laura W. J.} and Bernd Kremer and Speel, {Ernst-Jan M.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.",

year = "2021",

month = jan,

doi = "10.1002/hed.26513",

language = "English",

volume = "43",

pages = "303--322",

journal = "Head and Neck-Journal for the Sciences and Specialties of the Head and Neck",

issn = "1043-3074",

publisher = "Wiley",

number = "1",

}

Mulder, FJ , Pierssens, DDCG , Baijens, LWJ, Kremer, B & Speel, E-JM 2021, 'Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta-analysis on HPV, p16, and TP53', Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, vol. 43, no. 1, pp. 303-322. https://doi.org/10.1002/hed.26513

Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta-analysis on HPV, p16, and TP53. / Mulder, Frans J.; Pierssens, Damiana D. C. G.; Baijens, Laura W. J. et al.
In: Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, Vol. 43, No. 1, 01.2021, p. 303-322.

Research output: Contribution to journal › (Systematic) Review article › peer-review

TY - JOUR

T1 - Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers

T2 - Systematic review and meta-analysis on HPV, p16, and TP53

AU - Mulder, Frans J.

AU - Pierssens, Damiana D. C. G.

AU - Baijens, Laura W. J.

AU - Kremer, Bernd

AU - Speel, Ernst-Jan M.

PY - 2021/1

Y1 - 2021/1

N2 - Background The goal of this review was to present an overview of the currently identified molecular parameters in head and neck squamous cell carcinoma (HNSCC) of nonsmokers and nondrinkers (NSND).Methods Following the PRISMA guidelines, a systematic search was performed using the electronic databases PubMed, Embase, and Google Scholar.Results Of the 902 analyzed unique studies, 74 were included in a quantitative synthesis and 24 in a meta-analysis. Human papillomavirus (HPV) was reported as a molecular parameter in 38 studies, followed by p16 and TP53 (23 and 14 studies, respectively). The variety of other molecular parameters concerned sporadic findings in small numbers of NSND.Conclusions HNSCC in NSND is more often related to HPV and p16 overexpression compared to tumors of smokers-drinkers. In a third of virus-negative tumors, TP53 mutations were detected with a mutational profile associated with aging and ultraviolet light exposure rather than to tobacco consumption.

AB - Background The goal of this review was to present an overview of the currently identified molecular parameters in head and neck squamous cell carcinoma (HNSCC) of nonsmokers and nondrinkers (NSND).Methods Following the PRISMA guidelines, a systematic search was performed using the electronic databases PubMed, Embase, and Google Scholar.Results Of the 902 analyzed unique studies, 74 were included in a quantitative synthesis and 24 in a meta-analysis. Human papillomavirus (HPV) was reported as a molecular parameter in 38 studies, followed by p16 and TP53 (23 and 14 studies, respectively). The variety of other molecular parameters concerned sporadic findings in small numbers of NSND.Conclusions HNSCC in NSND is more often related to HPV and p16 overexpression compared to tumors of smokers-drinkers. In a third of virus-negative tumors, TP53 mutations were detected with a mutational profile associated with aging and ultraviolet light exposure rather than to tobacco consumption.

KW - head and neck cancer

KW - human papillomavirus

KW - nonsmokers

KW - p16

KW - TP53

KW - HUMAN-PAPILLOMAVIRUS INFECTION

KW - NON-DRINKING PATIENTS

KW - ORAL TONGUE

KW - OROPHARYNGEAL CANCER

KW - P53 EXPRESSION

KW - TOBACCO SMOKING

KW - NEVER-DRINKERS

KW - RISK-FACTORS

KW - CLINICOPATHOLOGICAL CHARACTERISTICS

KW - PROGNOSTIC BIOMARKERS

U2 - 10.1002/hed.26513

DO - 10.1002/hed.26513

M3 - (Systematic) Review article

C2 - 33098216

SN - 1043-3074

VL - 43

SP - 303

EP - 322

JO - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

JF - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

IS - 1

ER -

Mulder FJ , Pierssens DDCG , Baijens LWJ, Kremer B, Speel EJM. Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta-analysis on HPV, p16, and TP53. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 2021 Jan;43(1):303-322. Epub 2020 Oct 23. doi: 10.1002/hed.26513