Evidence-based proposal for the number of ambulatory readings required for assessing blood pressure level in research settings: an analysis of the IDACO database

Wen-Yi Yang, Lutgarde Thijs, Zhen-Yu Zhang, Kei Asayama, Jose Boggia, Tine W. Hansen, Takayoshi Ohkubo, Jorgen Jeppesen, Katarzyna Stolarz-Skrzypek, Sofia Malyutina, Edoardo Casiglia, Yuri Nikitin, Yan Li, Ji-Guang Wang, Yutaka Imai, Kalina Kawecka-Jaszcz, Eoin O'Brien, Jan A. Staessen*, International Database; on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    19 Citations (Web of Science)

    Abstract

    Background: Guidelines on the required number of ambulatory blood pressure (ABP) readings focus on individual patients. Clinical researchers often face the dilemma of applying recommendations and discarding potentially valuable information or accepting fewer readings. Methods: Starting from ABP recordings with >= 30/>= 10 awake/asleep readings in 4277 participants enrolled in eight population studies in the International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (IDACO), we randomly selected a certain number of readings (from 30 to 1 awake and 10 to 1 asleep readings) at a time over 1000 bootstraps at each step. We evaluated: (i) concordance of the ABP level; (ii) consistency of the cross-classification based on office blood pressure and ABP; and (iii) accuracy in predicting cardiovascular complications. For each criterion, we fitted a regression line joining data points relating outcome to the number of readings covering the ranges of 30-20/10-7 for awake/asleep readings. Results: Reducing readings widened the SD of the systolic/diastolic differences between full (reference) and selected recordings from 1.7/1.2 (30 readings) to 14.3/10.3 mm Hg (single reading) during wakefulness, and from 1.9/1.4 to 10.3/7.7 mm Hg during sleep; lowered the kappa statistic from 0.94 to 0.63, and decreased the hazard ratio associated with 10/5 mm Hg increments in systolic/diastolic ABP from 1.21/1.14 to 1.06/1.04 during wakefulness and from 1.26/1.17 to 1.14/1.08 during sleep. The first data points falling off these regression lines during wakefulness/sleep corresponded to 8/3 and 8/4 readings for criteria (i) and (iii) and to 5 awake readings for criterion (ii). Conclusions: 24-h ambulatory recordings with >= 8/>= 4 awake/asleep readings yielded ABP levels similar to recordings including the guideline-recommended >= 20/>= 7 readings. These criteria save valuable data in a research setting, but are not applicable to clinical practice.

    Original languageEnglish
    Pages (from-to)341-350
    Number of pages10
    JournalBlood Pressure
    Volume27
    Issue number6
    DOIs
    Publication statusPublished - 2 Nov 2018

    Keywords

    • Blood pressure monitoring
    • cardiovascular risk
    • diagnosis
    • hypertension
    • population science
    • EUROPEAN-SOCIETY
    • CUFF INFLATION
    • HYPERTENSION
    • POPULATION
    • RISK
    • ADULTS
    • INDIVIDUALS
    • VARIABILITY
    • THRESHOLDS
    • VALIDATION

    Cite this