Evidence-based practice within nutrition: what are the barriers for improving the evidence and how can they be dealt with?

Martine Laville; Berenice Segrestin; Maud Alligier; Cristina Ruano-Rodriguez; Lluis Serra-Majem; Michael Hiesmayr; Annemie Schols; Carlo La Vecchia; Yves Boirie; Ana Rath; Edmund A. M. Neugebauer; Silvio Garattini; Vittorio Bertele; Christine Kubiak; Jacques Demotes-Mainard; Janus C. Jakobsen; Snezana Djurisic; Christian Gluud

doi:10.1186/s13063-017-2160-8

Evidence-based practice within nutrition: what are the barriers for improving the evidence and how can they be dealt with?

Martine Laville, Berenice Segrestin, Maud Alligier, Cristina Ruano-Rodriguez, Lluis Serra-Majem, Michael Hiesmayr, Annemie Schols, Carlo La Vecchia, Yves Boirie, Ana Rath, Edmund A. M. Neugebauer, Silvio Garattini, Vittorio Bertele, Christine Kubiak, Jacques Demotes-Mainard, Janus C. Jakobsen, Snezana Djurisic^*, Christian Gluud^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Background: Evidence-based clinical research poses special barriers in the field of nutrition. The present review summarises the main barriers to research in the field of nutrition that are not common to all randomised clinical trials or trials on rare diseases and highlights opportunities for improvements.

Methods: Systematic academic literature searches and internal European Clinical Research Infrastructure Network (ECRIN) communications during face-to-face meetings and telephone conferences from 2013 to 2017 within the context of the ECRIN Integrating Activity (ECRIN-IA) project.

Results: Many nutrients occur in multiple forms that differ in biological activity, and several factors can alter their bioavailability which raises barriers to their assessment. These include specific difficulties with blinding procedures, with assessments of dietary intake, and with selecting appropriate outcomes as patient-centred outcomes may occur decennia into the future. The methodologies and regulations for drug trials are, however, applicable to nutrition trials.

Conclusions: Research on clinical nutrition should start by collecting clinical data systematically in databases and registries. Measurable patient-centred outcomes and appropriate study designs are needed. International cooperation and multistakeholder engagement are key for success.

Original language	English
Article number	425
Number of pages	9
Journal	Trials
Volume	18
DOIs	https://doi.org/10.1186/s13063-017-2160-8
Publication status	Published - 11 Sept 2017

Keywords

Randomised clinical trials
Evidence-based clinical practice
Evidence-based medicine
Assessment
Specific barriers
Nutrition
ECRIN
European Clinical Infrastructure Network
MEDITERRANEAN DIET
PROSPECTIVE COHORT
ADHERENCE
RISK
FOOD
EPIDEMIOLOGY
HEALTH
CANCER
COUNTRIES
SURVIVAL

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Cite this

Laville, M., Segrestin, B., Alligier, M., Ruano-Rodriguez, C., Serra-Majem, L., Hiesmayr, M., Schols, A., La Vecchia, C., Boirie, Y., Rath, A., Neugebauer, E. A. M., Garattini, S., Bertele, V., Kubiak, C., Demotes-Mainard, J., Jakobsen, J. C., Djurisic, S., & Gluud, C. (2017). Evidence-based practice within nutrition: what are the barriers for improving the evidence and how can they be dealt with? Trials, 18, Article 425. https://doi.org/10.1186/s13063-017-2160-8

@article{33b04e15ee96425798a4519141e4d723,

title = "Evidence-based practice within nutrition: what are the barriers for improving the evidence and how can they be dealt with?",

abstract = "Background: Evidence-based clinical research poses special barriers in the field of nutrition. The present review summarises the main barriers to research in the field of nutrition that are not common to all randomised clinical trials or trials on rare diseases and highlights opportunities for improvements.Methods: Systematic academic literature searches and internal European Clinical Research Infrastructure Network (ECRIN) communications during face-to-face meetings and telephone conferences from 2013 to 2017 within the context of the ECRIN Integrating Activity (ECRIN-IA) project.Results: Many nutrients occur in multiple forms that differ in biological activity, and several factors can alter their bioavailability which raises barriers to their assessment. These include specific difficulties with blinding procedures, with assessments of dietary intake, and with selecting appropriate outcomes as patient-centred outcomes may occur decennia into the future. The methodologies and regulations for drug trials are, however, applicable to nutrition trials.Conclusions: Research on clinical nutrition should start by collecting clinical data systematically in databases and registries. Measurable patient-centred outcomes and appropriate study designs are needed. International cooperation and multistakeholder engagement are key for success.",

keywords = "Randomised clinical trials, Evidence-based clinical practice, Evidence-based medicine, Assessment, Specific barriers, Nutrition, ECRIN, European Clinical Infrastructure Network, MEDITERRANEAN DIET, PROSPECTIVE COHORT, ADHERENCE, RISK, FOOD, EPIDEMIOLOGY, HEALTH, CANCER, COUNTRIES, SURVIVAL",

author = "Martine Laville and Berenice Segrestin and Maud Alligier and Cristina Ruano-Rodriguez and Lluis Serra-Majem and Michael Hiesmayr and Annemie Schols and {La Vecchia}, Carlo and Yves Boirie and Ana Rath and Neugebauer, {Edmund A. M.} and Silvio Garattini and Vittorio Bertele and Christine Kubiak and Jacques Demotes-Mainard and Jakobsen, {Janus C.} and Snezana Djurisic and Christian Gluud",

year = "2017",

month = sep,

day = "11",

doi = "10.1186/s13063-017-2160-8",

language = "English",

volume = "18",

journal = "Trials",

issn = "1745-6215",

publisher = "BioMed Central Ltd",

}

Laville, M, Segrestin, B, Alligier, M, Ruano-Rodriguez, C, Serra-Majem, L, Hiesmayr, M, Schols, A, La Vecchia, C, Boirie, Y, Rath, A, Neugebauer, EAM, Garattini, S, Bertele, V, Kubiak, C, Demotes-Mainard, J, Jakobsen, JC, Djurisic, S & Gluud, C 2017, 'Evidence-based practice within nutrition: what are the barriers for improving the evidence and how can they be dealt with?', Trials, vol. 18, 425. https://doi.org/10.1186/s13063-017-2160-8

TY - JOUR

T1 - Evidence-based practice within nutrition

T2 - what are the barriers for improving the evidence and how can they be dealt with?

AU - Laville, Martine

AU - Segrestin, Berenice

AU - Alligier, Maud

AU - Ruano-Rodriguez, Cristina

AU - Serra-Majem, Lluis

AU - Hiesmayr, Michael

AU - Schols, Annemie

AU - La Vecchia, Carlo

AU - Boirie, Yves

AU - Rath, Ana

AU - Neugebauer, Edmund A. M.

AU - Garattini, Silvio

AU - Bertele, Vittorio

AU - Kubiak, Christine

AU - Demotes-Mainard, Jacques

AU - Jakobsen, Janus C.

AU - Djurisic, Snezana

AU - Gluud, Christian

PY - 2017/9/11

Y1 - 2017/9/11

N2 - Background: Evidence-based clinical research poses special barriers in the field of nutrition. The present review summarises the main barriers to research in the field of nutrition that are not common to all randomised clinical trials or trials on rare diseases and highlights opportunities for improvements.Methods: Systematic academic literature searches and internal European Clinical Research Infrastructure Network (ECRIN) communications during face-to-face meetings and telephone conferences from 2013 to 2017 within the context of the ECRIN Integrating Activity (ECRIN-IA) project.Results: Many nutrients occur in multiple forms that differ in biological activity, and several factors can alter their bioavailability which raises barriers to their assessment. These include specific difficulties with blinding procedures, with assessments of dietary intake, and with selecting appropriate outcomes as patient-centred outcomes may occur decennia into the future. The methodologies and regulations for drug trials are, however, applicable to nutrition trials.Conclusions: Research on clinical nutrition should start by collecting clinical data systematically in databases and registries. Measurable patient-centred outcomes and appropriate study designs are needed. International cooperation and multistakeholder engagement are key for success.

AB - Background: Evidence-based clinical research poses special barriers in the field of nutrition. The present review summarises the main barriers to research in the field of nutrition that are not common to all randomised clinical trials or trials on rare diseases and highlights opportunities for improvements.Methods: Systematic academic literature searches and internal European Clinical Research Infrastructure Network (ECRIN) communications during face-to-face meetings and telephone conferences from 2013 to 2017 within the context of the ECRIN Integrating Activity (ECRIN-IA) project.Results: Many nutrients occur in multiple forms that differ in biological activity, and several factors can alter their bioavailability which raises barriers to their assessment. These include specific difficulties with blinding procedures, with assessments of dietary intake, and with selecting appropriate outcomes as patient-centred outcomes may occur decennia into the future. The methodologies and regulations for drug trials are, however, applicable to nutrition trials.Conclusions: Research on clinical nutrition should start by collecting clinical data systematically in databases and registries. Measurable patient-centred outcomes and appropriate study designs are needed. International cooperation and multistakeholder engagement are key for success.

KW - Randomised clinical trials

KW - Evidence-based clinical practice

KW - Evidence-based medicine

KW - Assessment

KW - Specific barriers

KW - Nutrition

KW - ECRIN

KW - European Clinical Infrastructure Network

KW - MEDITERRANEAN DIET

KW - PROSPECTIVE COHORT

KW - ADHERENCE

KW - RISK

KW - FOOD

KW - EPIDEMIOLOGY

KW - HEALTH

KW - CANCER

KW - COUNTRIES

KW - SURVIVAL

U2 - 10.1186/s13063-017-2160-8

DO - 10.1186/s13063-017-2160-8

M3 - (Systematic) Review article

C2 - 28893297

SN - 1745-6215

VL - 18

JO - Trials

JF - Trials

M1 - 425

ER -