Objectives: To investigate neurophysiological parameters which possibly distinguish subtypes I and II of patients with a bipolar disorder, and contrast the findings with observations from a group of schizophrenic patients and a group of healthy controls. Methods: Sixty-six volunteers underwent a MRI scan to determine the number and location of white matter lesions (WSL). A electrophysiological registration was made while all volunteers performed a auditory 'oddball' task, and the amplitude of the resulting P300 wave was compared. Results: Earlier reports of higher numbers of WSL in bipolar disorder were not replicated in this study. Subtypes I and II showed a different P300 amplitude and subtype I resembled the results of the schizophrenia group. Conclusion: Bipolar patients in remission have a functional brain disorder that is expressed by a change in physiological response to external stimuli.
Vuurman, E. F. P. M., Honig, A., Lamers, T. H., Wiersma, J., Krabbendam, A. C., Hofman, P. A. M., Nolen, W. A., & Jolles, J. (2002). Event related potentials and white matter lesions in bipolar disorder. Acta Neuropsychiatrica, 14, 11-16. https://doi.org/10.1034/j.1601-5215.2002.140102.x