TY - JOUR
T1 - Evaluation of the recently established Dutch nationwide Archipelago of Ovarian Cancer Research biobank
AU - Zelisse, Hein S
AU - van Gent, Mignon D J M
AU - Mom, Constantijne H
AU - de Ridder, Sander
AU - Snijders, Malou L H
AU - Heeling, Marlou
AU - Stoter, Matthijs
AU - Broeks, Annegien
AU - Horlings, Hugo M
AU - Lok, Christianne A R
AU - Bosch, Steven L
AU - Piek, Jurgen M
AU - Bart, Joost
AU - Reyners, Anna K L
AU - Wisman, G Bea A
AU - Yigit, Refika
AU - Boere, Ingrid A
AU - Collée, Margriet
AU - Groenendijk, Floris H
AU - Jansen, Maurice P H M
AU - Roes, Eva-Maria
AU - Hofhuis, Ward
AU - Hoogduin, Klaas J
AU - Alcalá, Luthy S M
AU - Smedts, Huberdina P M
AU - Makkus, Alexander C F
AU - Nieuwenhuyzen-de Boer, Gatske M
AU - van Es, Nicole
AU - Vencken, Peggy M L H
AU - van Altena, Anne M
AU - Simons, Michiel
AU - Hazelbag, Hans Marten
AU - Kagie, Marjolein J
AU - Aliredjo, Riena
AU - Bonestroo, Tijmen J J
AU - Bosse, Tjalling
AU - de Kroon, Cor D
AU - Brinkhuis, Mariël
AU - Janssen, Marc-Jan
AU - Koster, Nils C
AU - Kruse, Arnold-Jan
AU - Gerestein, Cornelis G
AU - Jonges, Trudy G N
AU - Zweemer, Ronald P
AU - Kooreman, Loes F S
AU - Lambrechts, Sandrina
AU - Ebisch, Inge M W
AU - de Kievit van der Heijden, Ineke M
AU - Voorham, Quirinus J
AU - van der Aa, Maaike A
AU - Dijk, F.
AU - Archipelago of Ovarian Cancer Research Consortium
PY - 2025/2
Y1 - 2025/2
N2 - Fundamental and translational research in ovarian cancer aims to enhance understanding of disease mechanisms and improve treatment and survival outcomes. To support this, we established the Dutch multicenter, interdisciplinary Archipelago of Ovarian Cancer Research (AOCR) infrastructure, which includes a nationwide biobank. In this study, we share our experiences in establishing the infrastructure, offer guidance for similar initiatives, and evaluate the AOCR patient cohort. Key challenges included obtaining Data Protection Impact Assessment (DPIA) clearance, drafting the consortium agreement, and securing ethical approval from all hospitals. Over three years, 1093 patients were enrolled across 17 hospitals, resulting in the collection of 1339 tissue samples and 2280 blood samples. Of the 523 patients with currently available clinical and pathological data, 74 % (n = 387) had primary ovarian cancer. Among these patients, 73.4 % was diagnosed with high-grade serous ovarian carcinoma, and 80.9 % presented with advanced-stage disease. Surgery was performed on 93 % of patients with primary ovarian cancer, and chemotherapy was administered to 90.4 % of these patients. In conclusion, the AOCR biobank has established a robust foundation for future fundamental and translational ovarian cancer research. This manuscript provides valuable insights and guidance for developing future research infrastructures and biobanks, and contains detailed information about the AOCR patient cohort to date.
AB - Fundamental and translational research in ovarian cancer aims to enhance understanding of disease mechanisms and improve treatment and survival outcomes. To support this, we established the Dutch multicenter, interdisciplinary Archipelago of Ovarian Cancer Research (AOCR) infrastructure, which includes a nationwide biobank. In this study, we share our experiences in establishing the infrastructure, offer guidance for similar initiatives, and evaluate the AOCR patient cohort. Key challenges included obtaining Data Protection Impact Assessment (DPIA) clearance, drafting the consortium agreement, and securing ethical approval from all hospitals. Over three years, 1093 patients were enrolled across 17 hospitals, resulting in the collection of 1339 tissue samples and 2280 blood samples. Of the 523 patients with currently available clinical and pathological data, 74 % (n = 387) had primary ovarian cancer. Among these patients, 73.4 % was diagnosed with high-grade serous ovarian carcinoma, and 80.9 % presented with advanced-stage disease. Surgery was performed on 93 % of patients with primary ovarian cancer, and chemotherapy was administered to 90.4 % of these patients. In conclusion, the AOCR biobank has established a robust foundation for future fundamental and translational ovarian cancer research. This manuscript provides valuable insights and guidance for developing future research infrastructures and biobanks, and contains detailed information about the AOCR patient cohort to date.
KW - Biobank
KW - Fundamental research
KW - Ovarian cancer
KW - Research infrastructure
KW - Translational research
U2 - 10.1016/j.anndiagpath.2024.152411
DO - 10.1016/j.anndiagpath.2024.152411
M3 - Article
SN - 1532-8198
VL - 74
JO - Annals of diagnostic pathology
JF - Annals of diagnostic pathology
M1 - 152411
ER -