Evaluation of the modifiedPittsburghclassification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal

Cindy H. Nabuurs; Wietske Kievit; Nilou Labbe BSc; C. Rene Leemans; Conrad F. G. M. Smit; Michiel W. M. van den Brekel; Robert J. Pauw; Bernard F. A. M. van der Laan; Jeroen C. Jansen; Martin Lacko; Weibel W. Braunius; Shinya Morita; Malgorzata Wierzbicka; Takuma Matoba; Nobuhiro Hanai; Robert P. Takes; Henricus P. M. Kunst

doi:10.1002/hed.26424

Evaluation of the modifiedPittsburghclassification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal

Cindy H. Nabuurs^*, Wietske Kievit, Nilou Labbe BSc, C. Rene Leemans, Conrad F. G. M. Smit, Michiel W. M. van den Brekel, Robert J. Pauw, Bernard F. A. M. van der Laan, Jeroen C. Jansen, Martin Lacko, Weibel W. Braunius, Shinya Morita, Malgorzata Wierzbicka, Takuma Matoba, Nobuhiro Hanai, Robert P. Takes, Henricus P. M. Kunst

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.

Original language	English
Pages (from-to)	3609-3622
Number of pages	14
Journal	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume	42
Issue number	12
Early online date	13 Aug 2020
DOIs	https://doi.org/10.1002/hed.26424
Publication status	Published - Dec 2020

Keywords

disease-free survival
neoplasm staging
prognosis
squamous cell carcinoma
temporal bone
TEMPORAL BONE RESECTION
MIDDLE-EAR
SURGICAL-TREATMENT
MALIGNANT-TUMORS
CANCER
RADIOTHERAPY
SURGERY
CHEMORADIOTHERAPY
PROGNOSIS

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Nabuurs, C. H., Kievit, W., BSc, N. L., Leemans, C. R., Smit, C. F. G. M., van den Brekel, M. W. M., Pauw, R. J., van der Laan, B. F. A. M., Jansen, J. C., Lacko, M., Braunius, W. W., Morita, S., Wierzbicka, M., Matoba, T., Hanai, N., Takes, R. P., & Kunst, H. P. M. (2020). Evaluation of the modifiedPittsburghclassification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 42(12), 3609-3622. https://doi.org/10.1002/hed.26424

@article{47607516c9344ea9869088a4f50cded6,

title = "Evaluation of the modifiedPittsburghclassification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal",

abstract = "Background Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.",

keywords = "disease-free survival, neoplasm staging, prognosis, squamous cell carcinoma, temporal bone, TEMPORAL BONE RESECTION, MIDDLE-EAR, SURGICAL-TREATMENT, MALIGNANT-TUMORS, CANCER, RADIOTHERAPY, SURGERY, CHEMORADIOTHERAPY, PROGNOSIS",

author = "Nabuurs, {Cindy H.} and Wietske Kievit and BSc, {Nilou Labbe} and Leemans, {C. Rene} and Smit, {Conrad F. G. M.} and {van den Brekel}, {Michiel W. M.} and Pauw, {Robert J.} and {van der Laan}, {Bernard F. A. M.} and Jansen, {Jeroen C.} and Martin Lacko and Braunius, {Weibel W.} and Shinya Morita and Malgorzata Wierzbicka and Takuma Matoba and Nobuhiro Hanai and Takes, {Robert P.} and Kunst, {Henricus P. M.}",

note = "Funding Information: The authors thank Gerjon Hannink, PhD, of the Department of Orthopedic Research Laboratory at Radboud University Medical Center for his assistance with statistical analysis. The authors thank Michael G. Moore MD, PhD (patient data coming from the Massachusetts Eye and Ear Infirmary, Boston MA), Luc G. T. Morris MD, MSc, Saral Mehra MD, MBA, Hirotaka Shinomiya MD, PhD, Hisashi Sugimoto MD, PhD, Wandee Khaimook MD and Jos{\'e} L. Llorente MD, PhD, for their contribution by providing their individual patient data of their studies. Publisher Copyright: {\textcopyright} 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.",

year = "2020",

month = dec,

doi = "10.1002/hed.26424",

language = "English",

volume = "42",

pages = "3609--3622",

journal = "Head and Neck-Journal for the Sciences and Specialties of the Head and Neck",

issn = "1043-3074",

publisher = "Wiley",

number = "12",

}

Nabuurs, CH, Kievit, W, BSc, NL, Leemans, CR, Smit, CFGM, van den Brekel, MWM, Pauw, RJ, van der Laan, BFAM, Jansen, JC, Lacko, M, Braunius, WW, Morita, S, Wierzbicka, M, Matoba, T, Hanai, N, Takes, RP & Kunst, HPM 2020, 'Evaluation of the modifiedPittsburghclassification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal', Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, vol. 42, no. 12, pp. 3609-3622. https://doi.org/10.1002/hed.26424

Evaluation of the modifiedPittsburghclassification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal. / Nabuurs, Cindy H.; Kievit, Wietske; BSc, Nilou Labbe et al.
In: Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, Vol. 42, No. 12, 12.2020, p. 3609-3622.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Evaluation of the modifiedPittsburghclassification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal

AU - Nabuurs, Cindy H.

AU - Kievit, Wietske

AU - BSc, Nilou Labbe

AU - Leemans, C. Rene

AU - Smit, Conrad F. G. M.

AU - van den Brekel, Michiel W. M.

AU - Pauw, Robert J.

AU - van der Laan, Bernard F. A. M.

AU - Jansen, Jeroen C.

AU - Lacko, Martin

AU - Braunius, Weibel W.

AU - Morita, Shinya

AU - Wierzbicka, Malgorzata

AU - Matoba, Takuma

AU - Hanai, Nobuhiro

AU - Takes, Robert P.

AU - Kunst, Henricus P. M.

N1 - Funding Information: The authors thank Gerjon Hannink, PhD, of the Department of Orthopedic Research Laboratory at Radboud University Medical Center for his assistance with statistical analysis. The authors thank Michael G. Moore MD, PhD (patient data coming from the Massachusetts Eye and Ear Infirmary, Boston MA), Luc G. T. Morris MD, MSc, Saral Mehra MD, MBA, Hirotaka Shinomiya MD, PhD, Hisashi Sugimoto MD, PhD, Wandee Khaimook MD and José L. Llorente MD, PhD, for their contribution by providing their individual patient data of their studies. Publisher Copyright: © 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.

PY - 2020/12

Y1 - 2020/12

N2 - Background Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.

AB - Background Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.

KW - disease-free survival

KW - neoplasm staging

KW - prognosis

KW - squamous cell carcinoma

KW - temporal bone

KW - TEMPORAL BONE RESECTION

KW - MIDDLE-EAR

KW - SURGICAL-TREATMENT

KW - MALIGNANT-TUMORS

KW - CANCER

KW - RADIOTHERAPY

KW - SURGERY

KW - CHEMORADIOTHERAPY

KW - PROGNOSIS

U2 - 10.1002/hed.26424

DO - 10.1002/hed.26424

M3 - Article

C2 - 32794253

SN - 1043-3074

VL - 42

SP - 3609

EP - 3622

JO - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

JF - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

IS - 12

ER -

Nabuurs CH, Kievit W, BSc NL, Leemans CR, Smit CFGM, van den Brekel MWM et al. Evaluation of the modifiedPittsburghclassification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 2020 Dec;42(12):3609-3622. Epub 2020 Aug 13. doi: 10.1002/hed.26424