Abstract
Background Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.
Original language | English |
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Pages (from-to) | 3609-3622 |
Number of pages | 14 |
Journal | Head and Neck-Journal for the Sciences and Specialties of the Head and Neck |
Volume | 42 |
Issue number | 12 |
Early online date | 13 Aug 2020 |
DOIs | |
Publication status | Published - Dec 2020 |
Keywords
- disease-free survival
- neoplasm staging
- prognosis
- squamous cell carcinoma
- temporal bone
- TEMPORAL BONE RESECTION
- MIDDLE-EAR
- SURGICAL-TREATMENT
- MALIGNANT-TUMORS
- CANCER
- RADIOTHERAPY
- SURGERY
- CHEMORADIOTHERAPY
- PROGNOSIS