Evaluation of the Interaction of Sex Hormones and Cardiovascular Function and Health

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

PURPOSE OF REVIEW: Sex hormones drive development and function of reproductive organs or the development of secondary sex characteristics but their effects on the cardiovascular system are poorly understood. In this review, we identify the gaps in our understanding of the interaction between sex hormones and the cardiovascular system.

RECENT FINDINGS: Studies are progressively elucidating molecular functions of sex hormones in specific cell types in parallel with the initiation of crucial large randomized controlled trials aimed at improving therapies for cardiovascular diseases (CVDs) associated with aberrant levels of sex hormones. In contrast with historical assumptions, we now understand that men and women show different symptoms and progression of CVDs. Abnormal levels of sex hormones pose an independent risk for CVD, which is apparent in conditions like Klinefelter syndrome, androgen insensitivity syndrome, and menopause. Moreover, sex hormone-based therapies remain understudied and may not be beneficial for cardiovascular health.

Original languageEnglish
Pages (from-to)200-212
Number of pages13
JournalCurrent Heart Failure Reports
Volume19
Issue number4
Early online date28 May 2022
DOIs
Publication statusPublished - Aug 2022

Keywords

  • CARDIOMYOCYTE HYPERTROPHY
  • CHRONIC HEART-FAILURE
  • Cardiovascular disease
  • EJECTION FRACTION
  • ELDERLY-MEN
  • ESTROGEN PLUS PROGESTIN
  • Heart failure
  • Hormone therapy
  • IN-VITRO
  • NITRIC-OXIDE
  • POSTMENOPAUSAL WOMEN
  • REPLACEMENT THERAPY
  • Sex hormones
  • TESTOSTERONE

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