Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal

Cindy H Nabuurs; Wietske Kievit; C René Leemans; Conrad F G M Smit; Michiel W M van den Brekel; Robert J Pauw; Bernard F A M van der Laan; Jeroen C Jansen; Martin Lacko; Weibel W Braunius; Chunfu Dai; Xunbei Shi; Giovanni Danesi; Jan Bouček; Robert P Takes; Henricus P M Kunst

doi:10.1002/hed.27082

Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal

Cindy H Nabuurs^*, Wietske Kievit, C René Leemans, Conrad F G M Smit, Michiel W M van den Brekel, Robert J Pauw, Bernard F A M van der Laan, Jeroen C Jansen, Martin Lacko, Weibel W Braunius, Chunfu Dai, Xunbei Shi, Giovanni Danesi, Jan Bouček, Robert P Takes, Henricus P M Kunst

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti.

METHODS: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated.

RESULTS: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass.

CONCLUSION: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.

Original language	English
Pages (from-to)	1787-1798
Number of pages	12
Journal	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume	44
Issue number	8
Early online date	13 May 2022
DOIs	https://doi.org/10.1002/hed.27082
Publication status	Published - Aug 2022

Keywords

CONCOMITANT CHEMORADIOTHERAPY
MANAGEMENT
RADICAL SURGERY
RADIOTHERAPY
SURGICAL-TREATMENT
SURVIVAL OUTCOMES
TEMPORAL BONE RESECTION
disease-free survival
neoplasm staging
squamous cell carcinoma
temporal bone
treatment

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10.1002/hed.27082Licence: CC BY-NC-ND

Cite this

Nabuurs, C. H., Kievit, W., Leemans, C. R., Smit, C. F. G. M., van den Brekel, M. W. M., Pauw, R. J., van der Laan, B. F. A. M., Jansen, J. C., Lacko, M., Braunius, W. W., Dai, C., Shi, X., Danesi, G., Bouček, J., Takes, R. P., & Kunst, H. P. M. (2022). Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 44(8), 1787-1798. https://doi.org/10.1002/hed.27082

@article{90b465f73f0a487b811e827e1889efab,

title = "Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal",

abstract = "BACKGROUND: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti.METHODS: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated.RESULTS: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass.CONCLUSION: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.",

keywords = "CONCOMITANT CHEMORADIOTHERAPY, MANAGEMENT, RADICAL SURGERY, RADIOTHERAPY, SURGICAL-TREATMENT, SURVIVAL OUTCOMES, TEMPORAL BONE RESECTION, disease-free survival, neoplasm staging, squamous cell carcinoma, temporal bone, treatment",

author = "Nabuurs, {Cindy H} and Wietske Kievit and Leemans, {C Ren{\'e}} and Smit, {Conrad F G M} and {van den Brekel}, {Michiel W M} and Pauw, {Robert J} and {van der Laan}, {Bernard F A M} and Jansen, {Jeroen C} and Martin Lacko and Braunius, {Weibel W} and Chunfu Dai and Xunbei Shi and Giovanni Danesi and Jan Bou{\v c}ek and Takes, {Robert P} and Kunst, {Henricus P M}",

note = "{\textcopyright} 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.",

year = "2022",

month = aug,

doi = "10.1002/hed.27082",

language = "English",

volume = "44",

pages = "1787--1798",

journal = "Head and Neck-Journal for the Sciences and Specialties of the Head and Neck",

issn = "1043-3074",

publisher = "Wiley",

number = "8",

}

Nabuurs, CH, Kievit, W, Leemans, CR, Smit, CFGM, van den Brekel, MWM, Pauw, RJ, van der Laan, BFAM, Jansen, JC, Lacko, M, Braunius, WW, Dai, C, Shi, X, Danesi, G, Bouček, J, Takes, RP & Kunst, HPM 2022, 'Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal', Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, vol. 44, no. 8, pp. 1787-1798. https://doi.org/10.1002/hed.27082

TY - JOUR

T1 - Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal

AU - Nabuurs, Cindy H

AU - Kievit, Wietske

AU - Leemans, C René

AU - Smit, Conrad F G M

AU - van den Brekel, Michiel W M

AU - Pauw, Robert J

AU - van der Laan, Bernard F A M

AU - Jansen, Jeroen C

AU - Lacko, Martin

AU - Braunius, Weibel W

AU - Dai, Chunfu

AU - Shi, Xunbei

AU - Danesi, Giovanni

AU - Bouček, Jan

AU - Takes, Robert P

AU - Kunst, Henricus P M

PY - 2022/8

Y1 - 2022/8

N2 - BACKGROUND: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti.METHODS: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated.RESULTS: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass.CONCLUSION: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.

AB - BACKGROUND: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti.METHODS: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated.RESULTS: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass.CONCLUSION: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.

KW - CONCOMITANT CHEMORADIOTHERAPY

KW - MANAGEMENT

KW - RADICAL SURGERY

KW - RADIOTHERAPY

KW - SURGICAL-TREATMENT

KW - SURVIVAL OUTCOMES

KW - TEMPORAL BONE RESECTION

KW - disease-free survival

KW - neoplasm staging

KW - squamous cell carcinoma

KW - temporal bone

KW - treatment

U2 - 10.1002/hed.27082

DO - 10.1002/hed.27082

M3 - Article

C2 - 35560966

SN - 1043-3074

VL - 44

SP - 1787

EP - 1798

JO - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

JF - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

IS - 8

ER -