Evaluation of in vitro immunotoxicity tests using transcriptomics

P.C.J. Schmeits

    Research output: ThesisDoctoral ThesisInternal

    429 Downloads (Pure)

    Abstract

    Peter Schmeits researched the detection of substances that are toxic to immune cells by culturing different cell lines in plastic containers and exposing them to toxic and non-toxic substances for immune cells. He then measured the effects on the activation of all genes (roughly 22,000 messenger RNAs). This generated new insights into the substances' modes of action. Previous research has identified a group of twenty-five marker genes that can predict the toxicity of a substance for the immune system, which was confirmed in a new experiment using different substances. This alternative method may one day be replicated using animal studies.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Maastricht University
    Supervisors/Advisors
    • van Loveren, Henk, Supervisor
    • Peijnenburg, A., Co-Supervisor, External person
    Award date13 Nov 2015
    Place of Publication's-Hertogenbosch
    Publisher
    Print ISBNs9789462952775
    DOIs
    Publication statusPublished - 2015

    Keywords

    • toxic substances
    • immune cells
    • in vitro

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