Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study

Inca H. R. Hundscheid*, Dirk H. S. M. Schellekens, Joep Grootjans, Marcel Den Dulk, Ronald M. Van Dam, Geerard L. Beets, Wim A. Buurman, Kaatje Lenaerts, Joep P. M. Derikx, Cornelis H. C. Dejong

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background

We developed a jejunal and colonic experimental human ischemia-reperfusion (IR) model to study pathophysiological intestinal IR mechanisms and potential new intestinal ischemia biomarkers. Our objective was to evaluate the safety of these IR models by comparing patients undergoing surgery with and without in vivo intestinal IR.

Methods

A retrospective study was performed comparing complication rates and severity, based on the Clavien-Dindo classification system, in patients undergoing pancreatoduodenectomy with (n = 10) and without (n = 20 matched controls) jejunal IR or colorectal surgery with (n = 10) and without (n = 20 matched controls) colon IR. Secondary outcome parameters were operative time, blood loss, 90-day mortality and length of hospital stay.

Results

Following pancreatic surgery, 63% of the patients experienced one or more postoperative complications. There was no significant difference in incidence or severity of complications between patients undergoing pancreatic surgery with (70%) or without (60%, P = 0.7) jejunal IR. Following colorectal surgery, 60% of the patients experienced one or more postoperative complication. Complication rate and severity were similar in patients with (50%) and without (65%, P = 0.46) colonic IR. Operative time, amount of blood loss, postoperative C-reactive protein, length of hospital stay or mortality were equal in both intervention and control groups for jejunal and colon IR.

Conclusion

This study showed that human experimental intestinal IR models are safe in patients undergoing pancreatic or colorectal surgery.

Original languageEnglish
Article number0253506
Number of pages15
JournalPLOS ONE
Volume16
Issue number6
DOIs
Publication statusPublished - 18 Jun 2021

Keywords

  • INTERNATIONAL STUDY-GROUP
  • PANCREATIC SURGERY
  • ORGAN DYSFUNCTION
  • COMPLICATIONS
  • CANCER
  • COLON
  • MANAGEMENT
  • MORTALITY
  • OUTCOMES

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