TY - JOUR
T1 - Evaluating and comparing tolerance, nutritional quality and bio-functional activity of bovine-plasma, corn and whey proteins, outcomes of a randomized double blind controlled trial
AU - Esser, Diederik
AU - Wehrens, Ron
AU - Lenaerts, Kaatje
AU - Engel, Jasper
AU - van den Dool, Ronald T.M.
AU - Bastiaan-Net, Shanna
AU - Mes, Jurriaan J.
AU - Wichers, Harry J.
N1 - Funding Information:
This project received financial support from the Agri & Food Top Sector program of the Dutch Ministry of Agriculture Nature and Food Quality, and the Sustainable Future Proteins-consortium (TKI-AF 15,269) in collaboration with BASF, Cargill, Coöperate AVEBE U.A., Darling Ingredients, Lesaffre, Marlow Foods, PepsiCo, Roquette, Mimetas B.V., Danone Nutricia Research and Proti-Farm R&D B.V. The views expressed in this manuscript are those of the authors and do not necessarily reflect the position or policy of the collaborating companies.
Funding Information:
We kindly acknowledge the financial support from the Agri & Food Top Sector. Within the Top Sector, the business community, knowledge institutions and the government work together on innovations for safe and healthy food for 9 billion people in a resilient world.
Funding Information:
This project received financial support from the Agri & Food Top Sector program of the Dutch Ministry of Agriculture Nature and Food Quality , and the S ustainable Future Proteins-consortium ( TKI-AF 15,269 ) in collaboration with BASF, Cargill, Coöperate AVEBE U.A., Darling Ingredients, Lesaffre, Marlow Foods, PepsiCo, Roquette, Mimetas B.V., Danone Nutricia Research and Proti-Farm R&D B.V. The views expressed in this manuscript are those of the authors and do not necessarily reflect the position or policy of the collaborating companies.
Publisher Copyright:
© 2023 The Authors
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Important considerations in the choice of future sustainable protein sources for human application are tolerance, nutritional quality, and potential health benefits. We evaluated, in a double-blind cross-over intervention trial, tolerance, nutritional quality, and potential health effects of two sustainable protein sources. Thirty-six apparently healthy older adults (age 62.3 ± 7.2yrs, BMI 25 ± 3 kg/m2) received 40 g/day bovine-plasma protein (BP), corn protein (CP) or, as a benchmark, whey protein (WP) for one week with a washout period of one week in-between. In 12 participants, we also determined postprandial amino acid (PAA) uptake kinetics upon consumption of 20 g BP, CP, or WP. Changes in self-reported gastrointestinal complaints and intestinal permeability assessed using a multi-sugar acetylsalicylic acid test did not differ between the interventions. Clear differences in PAA responses were observed after consumption of the different proteins, but clear essential amino acid responses were observed for all proteins. BP consumption resulted in a small but significant increase in blood pressure outcomes, and CP consumption resulted in a small but significant decrease in insulin levels when compared to the other interventions. In conclusion, alternative protein concentrates and isolates studied here can be consumed in relative high quantities without experiencing unwanted GI complaints or gut barrier dysfunction and they can be a good source of essential amino acids. The rise in blood pressure observed during the BP intervention, potentially linked to the elevated salt content of the BP, constitutes a potential health issue. Future studies with longer intervention periods might however be recommended.
AB - Important considerations in the choice of future sustainable protein sources for human application are tolerance, nutritional quality, and potential health benefits. We evaluated, in a double-blind cross-over intervention trial, tolerance, nutritional quality, and potential health effects of two sustainable protein sources. Thirty-six apparently healthy older adults (age 62.3 ± 7.2yrs, BMI 25 ± 3 kg/m2) received 40 g/day bovine-plasma protein (BP), corn protein (CP) or, as a benchmark, whey protein (WP) for one week with a washout period of one week in-between. In 12 participants, we also determined postprandial amino acid (PAA) uptake kinetics upon consumption of 20 g BP, CP, or WP. Changes in self-reported gastrointestinal complaints and intestinal permeability assessed using a multi-sugar acetylsalicylic acid test did not differ between the interventions. Clear differences in PAA responses were observed after consumption of the different proteins, but clear essential amino acid responses were observed for all proteins. BP consumption resulted in a small but significant increase in blood pressure outcomes, and CP consumption resulted in a small but significant decrease in insulin levels when compared to the other interventions. In conclusion, alternative protein concentrates and isolates studied here can be consumed in relative high quantities without experiencing unwanted GI complaints or gut barrier dysfunction and they can be a good source of essential amino acids. The rise in blood pressure observed during the BP intervention, potentially linked to the elevated salt content of the BP, constitutes a potential health issue. Future studies with longer intervention periods might however be recommended.
KW - Dietary protein
KW - Health
KW - Nutrient quality
KW - Protein concentrates isolates
KW - Tolerance
U2 - 10.1016/j.crfs.2023.100588
DO - 10.1016/j.crfs.2023.100588
M3 - Article
VL - 7
JO - Current Research in Food Science
JF - Current Research in Food Science
IS - 1
M1 - 100588
ER -