TY - JOUR
T1 - European Respiratory Society guidelines for the management of adult bronchiectasis
AU - Polverino, Eva
AU - Goeminne, Pieter C.
AU - McDonnell, Melissa J.
AU - Aliberti, Stefano
AU - Marshall, Sara E.
AU - Loebinger, Michael R.
AU - Murris, Marlene
AU - Canton, Rafael
AU - Torres, Antoni
AU - Dimakou, Katerina
AU - De Soyza, Anthony
AU - Hill, Adam T.
AU - Haworth, Charles S.
AU - Vendrell, Montserrat
AU - Ringshausen, Felix C.
AU - Subotic, Dragan
AU - Wilson, Robert
AU - Vilaro, Jordi
AU - Stallberg, Bjorn
AU - Welte, Tobias
AU - Rohde, Gernot
AU - Blasi, Francesco
AU - Elborn, Stuart
AU - Almagro, Marta
AU - Timothy, Alan
AU - Ruddy, Thomas
AU - Tonia, Thomy
AU - Rigau, David
AU - Chalmers, James D.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent exacerbations in many patients. There have been no previous international guidelines.The European Respiratory Society guidelines for the management of adult bronchiectasis describe the appropriate investigation and treatment strategies determined by a systematic review of the literature.A multidisciplinary group representing respiratory medicine, microbiology, physiotherapy, thoracic surgery, primary care, methodology and patients considered the most relevant clinical questions (for both clinicians and patients) related to management of bronchiectasis. Nine key clinical questions were generated and a systematic review was conducted to identify published systematic reviews, randomised clinical trials and observational studies that answered these questions. We used the GRADE approach to define the quality of the evidence and the level of recommendations. The resulting guideline addresses the investigation of underlying causes of bronchiectasis, treatment of exacerbations, pathogen eradication, long term antibiotic treatment, anti-inflammatories, mucoactive drugs, bronchodilators, surgical treatment and respiratory physiotherapy.These recommendations can be used to benchmark quality of care for people with bronchiectasis across Europe and to improve outcomes.
AB - Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent exacerbations in many patients. There have been no previous international guidelines.The European Respiratory Society guidelines for the management of adult bronchiectasis describe the appropriate investigation and treatment strategies determined by a systematic review of the literature.A multidisciplinary group representing respiratory medicine, microbiology, physiotherapy, thoracic surgery, primary care, methodology and patients considered the most relevant clinical questions (for both clinicians and patients) related to management of bronchiectasis. Nine key clinical questions were generated and a systematic review was conducted to identify published systematic reviews, randomised clinical trials and observational studies that answered these questions. We used the GRADE approach to define the quality of the evidence and the level of recommendations. The resulting guideline addresses the investigation of underlying causes of bronchiectasis, treatment of exacerbations, pathogen eradication, long term antibiotic treatment, anti-inflammatories, mucoactive drugs, bronchodilators, surgical treatment and respiratory physiotherapy.These recommendations can be used to benchmark quality of care for people with bronchiectasis across Europe and to improve outcomes.
KW - CYSTIC-FIBROSIS BRONCHIECTASIS
KW - RANDOMIZED CONTROLLED-TRIAL
KW - OBSTRUCTIVE PULMONARY-DISEASE
KW - QUALITY-OF-LIFE
KW - PSEUDOMONAS-AERUGINOSA INFECTION
KW - CHRONIC BRONCHIAL INFECTION
KW - PLACEBO-CONTROLLED TRIAL
KW - LUNG-FUNCTION DECLINE
KW - LONG-TERM
KW - DOUBLE-BLIND
U2 - 10.1183/13993003.00629-2017
DO - 10.1183/13993003.00629-2017
M3 - Article
SN - 0903-1936
VL - 50
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 3
M1 - 1700629
ER -