European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Lisa Vermunt*, Colin D. Veal, Lea ter Meulen, Charalambos Chrysostomou, Wiesje van der Flier, Giovanni B. Frisoni, Idris Guessous, Miia Kivipelto, Moira Marizzoni, Pablo Martinez-Lage, Jose Molinuevo, David Porteous, Karen Ritchie, Philip Scheltens, Pierre-Jean Ousset, Craig W. Ritchie, Gerald Luscan, Anthony J. Brookes, Pieter Jelle Visser

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Methods: Avirtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)837-842
Number of pages6
JournalAlzheimer's & Dementia
Issue number6
Publication statusPublished - 1 Jun 2018


  • Preclinical AD
  • Prodromal AD
  • Clinical trial
  • Participant recruitment
  • Research registry
  • EPAD

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