TY - JOUR
T1 - European Prevention of Alzheimer's Dementia Registry
T2 - Recruitment and prescreening approach for a longitudinal cohort and prevention trials
AU - Vermunt, Lisa
AU - Veal, Colin D.
AU - ter Meulen, Lea
AU - Chrysostomou, Charalambos
AU - van der Flier, Wiesje
AU - Frisoni, Giovanni B.
AU - Guessous, Idris
AU - Kivipelto, Miia
AU - Marizzoni, Moira
AU - Martinez-Lage, Pablo
AU - Molinuevo, Jose
AU - Porteous, David
AU - Ritchie, Karen
AU - Scheltens, Philip
AU - Ousset, Pierre-Jean
AU - Ritchie, Craig W.
AU - Luscan, Gerald
AU - Brookes, Anthony J.
AU - Visser, Pieter Jelle
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Methods: Avirtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
AB - Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Methods: Avirtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
KW - Preclinical AD
KW - Prodromal AD
KW - Clinical trial
KW - Participant recruitment
KW - Research registry
KW - EPAD
U2 - 10.1016/j.jalz.2018.02.010
DO - 10.1016/j.jalz.2018.02.010
M3 - Article
SN - 1552-5260
VL - 14
SP - 837
EP - 842
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
IS - 6
ER -