European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 1. epidemiology, diagnostics and prevention

Alexander J. Stratigos*, Claus Garbe, Clio Dessinioti, Celeste Lebbe, Veronique Bataille, Lars Bastholt, Brigitte Dreno, Maria Concetta Fargnoli, Ana Maria Forsea, Cecille Frenard, Catherine A. Harwood, Axel Hauschild, Christoph Hoeller, Lidija Kandolf-Sekulovic, R. Kaufmann, Nicole W. J. Kelleners-Smeets, Josep Malvehy, Veronique del Marmol, Mark R. Middleton, David Moreno-RamirezGiovanni Pellecani, Ketty Peris, Philippe Saiag, Marieke H. J. van den Beuken-van Everdingen, Ricardo Vieira, Iris Zalaudek, Alexander M. M. Eggermont, Jean-Jacques Grob, European Dermatology Forum (EDF), European Association of Dermato-Oncology (EADO), European Organization for Research and Treatment of Cancer (EORTC)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Web of Science)

Abstract

Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the white populations, accounting for 20% of all cutaneous malignancies. Factors implicated in cSCC etiopathogenesis include ultraviolet radiation exposure and chronic photoaging, age, male sex, immunosuppression, smoking and genetic factors. A collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organisation of Research and Treatment of Cancer (EORTC) was formed to update recommendations on cSCC classification, diagnosis, risk stratification, staging and prevention, based on current literature, staging systems and expert consensus. Common cSCCs are typically indolent tumors, and most have a good prognosis with 5-year cure rates of greater than 90%, and a low rate of metastases (

Original languageEnglish
Pages (from-to)60-82
Number of pages23
JournalEuropean Journal of Cancer
Volume128
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Invasive cutaneous squamous cell carcinoma
  • Low-risk
  • High-risk common primary cSCC
  • Locally advanced Cscc
  • Metastatic cSCC
  • Diagnosis
  • Prognosis
  • Staging
  • Imaging
  • Prevention
  • LYMPH-NODE BIOPSY
  • ORGAN TRANSPLANT RECIPIENTS
  • RANDOMIZED CONTROLLED-TRIAL
  • AMERICAN JOINT COMMITTEE
  • NONSTEROIDAL ANTIINFLAMMATORY DRUGS
  • HIGH-RISK
  • BASAL-CELL
  • SUN PROTECTION
  • CANCER PREVENTION
  • PERINEURAL INVASION

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