TY - JOUR
T1 - European consensus-based interdisciplinary guideline for melanoma. Part 1
T2 - Diagnostics: Update 2022
AU - Garbe, Claus
AU - Amaral, Teresa
AU - Peris, Ketty
AU - Hauschild, Axel
AU - Arenberger, Petr
AU - Basset-Seguin, Nicole
AU - Bastholt, Lars
AU - Bataille, Veronique
AU - Del Marmol, Veronique
AU - Dréno, Brigitte
AU - Fargnoli, Maria C
AU - Forsea, Ana-Maria
AU - Grob, Jean-Jacques
AU - Höller, Christoph
AU - Kaufmann, Roland
AU - Kelleners-Smeets, Nicole
AU - Lallas, Aimilios
AU - Lebbé, Celeste
AU - Lytvynenko, Bodhan
AU - Malvehy, Josep
AU - Moreno-Ramirez, David
AU - Nathan, Paul
AU - Pellacani, Giovanni
AU - Saiag, Philippe
AU - Stratigos, Alexander J
AU - Van Akkooi, Alexander C J
AU - Vieira, Ricardo
AU - Zalaudek, Iris
AU - Lorigan, Paul
AU - European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
N1 - Copyright © 2022 Elsevier Ltd. All rights reserved.
PY - 2022/7
Y1 - 2022/7
N2 - Cutaneous melanoma (CM) is potentially the most dangerous form of skin tumor and causes 90% of skin cancer mortality. A unique collaboration of multi-disciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC) was formed to make recommendations on CM diagnosis and treatment, based on systematic literature reviews and the experts' experience. The diagnosis of melanoma can be made clinically and shall always be confirmed with dermatoscopy. If a melanoma is suspected, a histopathological examination is always required. Sequential digital dermatoscopy and full body photography can be used in high-risk patients to improve the detection of early melanoma. Where available, confocal reflectance microscopy can also improve clinical diagnosis in special cases. Melanoma shall be classified according to the 8th version of the American Joint Committee on Cancer classification. Thin melanomas up to 0.8 mm tumor thickness do not require further imaging diagnostics. From stage IB onwards, examinations with lymph node sonography are recommended, but no further imaging examinations. From stage IIC onwards whole-body examinations with computed tomography (CT) or positron emission tomography CT (PET-CT) in combination with brain magnetic resonance imaging are recommended. From stage III and higher, mutation testing is recommended, particularly for BRAF V600 mutation. It is important to provide a structured follow-up to detect relapses and secondary primary melanomas as early as possible. There is no evidence to define the frequency and extent of examinations. A stage-based follow-up scheme is proposed which, according to the experience of the guideline group, covers the optimal requirements, but further studies may be considered. This guideline is valid until the end of 2024.
AB - Cutaneous melanoma (CM) is potentially the most dangerous form of skin tumor and causes 90% of skin cancer mortality. A unique collaboration of multi-disciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC) was formed to make recommendations on CM diagnosis and treatment, based on systematic literature reviews and the experts' experience. The diagnosis of melanoma can be made clinically and shall always be confirmed with dermatoscopy. If a melanoma is suspected, a histopathological examination is always required. Sequential digital dermatoscopy and full body photography can be used in high-risk patients to improve the detection of early melanoma. Where available, confocal reflectance microscopy can also improve clinical diagnosis in special cases. Melanoma shall be classified according to the 8th version of the American Joint Committee on Cancer classification. Thin melanomas up to 0.8 mm tumor thickness do not require further imaging diagnostics. From stage IB onwards, examinations with lymph node sonography are recommended, but no further imaging examinations. From stage IIC onwards whole-body examinations with computed tomography (CT) or positron emission tomography CT (PET-CT) in combination with brain magnetic resonance imaging are recommended. From stage III and higher, mutation testing is recommended, particularly for BRAF V600 mutation. It is important to provide a structured follow-up to detect relapses and secondary primary melanomas as early as possible. There is no evidence to define the frequency and extent of examinations. A stage-based follow-up scheme is proposed which, according to the experience of the guideline group, covers the optimal requirements, but further studies may be considered. This guideline is valid until the end of 2024.
KW - ACRAL LENTIGINOUS MELANOMA
KW - AJCC classification
KW - AMERICAN JOINT COMMITTEE
KW - CUTANEOUS MELANOMA
KW - Confocal reflectance microscopy
KW - Cutaneous melanoma
KW - Dermatoscopy
KW - FOLLOW-UP
KW - Follow-up examinations
KW - Imaging diagnostics
KW - MALIGNANT-MELANOMA
KW - MELANOCYTIC NEVI
KW - Mutation testing
KW - NEEDLE-ASPIRATION-CYTOLOGY
KW - Primary diagnosis
KW - REFLECTANCE CONFOCAL MICROSCOPY
KW - SENTINEL-NODE BIOPSY
KW - Sequential digital
KW - TOTAL-BODY PHOTOGRAPHY
KW - Total body photography
KW - dermatoscopy
U2 - 10.1016/j.ejca.2022.03.008
DO - 10.1016/j.ejca.2022.03.008
M3 - (Systematic) Review article
C2 - 35570085
SN - 0959-8049
VL - 170
SP - 236
EP - 255
JO - European Journal of Cancer
JF - European Journal of Cancer
ER -