European Birth Cohorts for Environmental Health Research

Martine Vrijheid*, Maribel Casas, Anna Bergstrom, Amanda Carmichael, Sylvaine Cordier, Merete Eggesbo, Esben Eller, Maria P. Fantini, Mariana F. Fernandez, Ana Fernandez-Somoano, Ulrike Gehring, Regina Grazuleviciene, Cynthia Hohmann, Anne M. Karvonen, Thomas Keil, Manolis Kogevinas, Gudrun Koppen, Ursula Kraemer, Claudia E. Kuehni, Per MagnusRenata Majewska, Anne-Marie Nybo Andersen, Evridiki Patelarou, Maria Skaalum Petersen, Frank H. Pierik, Kinga Polanska, Daniela Porta, Lorenzo Richiardi, Ana Cristina Santos, Remy Slama, Radim J. Sram, Care Thijs, Christina Tischer, Gunnar Toft, Tomas Trnovec, Stephanie Vandentorren, Tanja G. M. Vrijkotte, Michael Wilhelm, John Wright, Mark J. Nieuwenhuijsen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: Many pregnancy and birth cohort studies investigate the health effects of early-life environmental contaminant exposure. An overview of existing studies and their data is needed to improve collaboration, harmonization, and future project planning. OBJECTIVES: Our goal was to create a comprehensive overview of European birth cohorts with environmental exposure data. METHODS: Birth cohort studies were included if they a) collected data on at least one environmental exposure, b) started enrollment during pregnancy or at birth, c) included at least one follow-up point after birth, d) included at least 200 mother-child pairs, and e) were based in a European country. A questionnaire collected information on basic protocol details and exposure and health outcome assessments, including specific contaminants, methods and samples, timing, and number of subjects. A full inventory can be searched on RESULTS: Questionnaires were completed by 37 cohort studies of > 350,000 mother-child pairs in 19 European countries. Only three cohorts did not participate. All cohorts collected biological specimens of children or parents. Many cohorts collected information on passive smoking (n = 36), maternal occupation (n = 33), outdoor air pollution (n = 27), and allergens/biological organisms (n = 27). Fewer cohorts (n = 12-19) collected information on water contamination, ionizing or nonionizing radiation exposures, noise, metals, persistent organic pollutants, or other pollutants. All cohorts have information on birth outcomes; nearly all on asthma, allergies, childhood growth and obesity; and 26 collected information on child neurodevelopment. CONCLUSION: Combining forces in this field will yield more efficient and conclusive studies and ultimately improve causal inference. This impressive resource of existing birth cohort data could form the basis for longer-term and worldwide coordination of research on environment and child health.
Original languageEnglish
Pages (from-to)29-37
JournalEnvironmental Health Perspectives
Issue number1
Publication statusPublished - Jan 2012


  • birth cohorts
  • child health
  • environmental exposures
  • Europe
  • review

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