EURODIAB Prospective Complications Study Group Serum HSP27 and diabetes complications in the Eurodiab Prospective Complications Study: a novel circulating marker for diabetic neuropathy

G. Gruden, G. Bruno, N. Cahturvedi, D. Burt, C.G. Schalkwijk, S. Pinach, C.D.A. Stehouwer, D.R. Witte, J.F. Fuller, P. Cavallo Perin

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Abstract

OBJECTIVE-Heat shock protein 27 (HSP27) is a member of the small heat shock protein family of proteins. HSP27 expression is enhanced in target tissues of diabetic microvascular complications, and changes in circulating serum HSP27 levels (sHSP27) have been reported in patients with macrovascular disease. We investigated whether sHSP27 levels were associated with micro- and macrovascular complications in type 1 diabetic patients. RESEARCH DESIGN AND METHODS-A cross-sectional, nested, case-control study from the EURODLAB Prospective Complications Study of 531 type 1 diabetic patients was performed. Case subjects (n = 363) were defined as those with one or more complications of diabetes; control subjects (n = 168) were defined as those with no evidence of any complication. We measured sHSP27 levels and investigated their associations with diabetes complications. RESULTS-Mean sHSP27 levels were significantly higher in case subjects with distal symmetrical polyneuropathy (DSP) than in control subjects, even after adjustment for age and albumin excretion rate (AER) (785.9 vs. 574.7 pg/ml, P = 0.03). In logistic regression analysis, sHSP27 levels in the upper quartile were associated with a twofold increased odds ratio (OR) of DSP, independently of conventional risk factors, markers of inflammation, and AER (OR 2.41 [959/o CI 1.11-5.24]). CONCLUSIONS-In this large cohort of type 1 diabetic subjects, we found an independent association between sHSP27 and DSP. This suggests that sHSP27 levels may be a novel marker for diabetic neuropathy.
Original languageEnglish
Pages (from-to)1966-70
JournalDiabetes
Volume57
DOIs
Publication statusPublished - 1 Jan 2008

Cite this

@article{5db90f72d7b74480af46ae91f234ea60,
title = "EURODIAB Prospective Complications Study Group Serum HSP27 and diabetes complications in the Eurodiab Prospective Complications Study: a novel circulating marker for diabetic neuropathy",
abstract = "OBJECTIVE-Heat shock protein 27 (HSP27) is a member of the small heat shock protein family of proteins. HSP27 expression is enhanced in target tissues of diabetic microvascular complications, and changes in circulating serum HSP27 levels (sHSP27) have been reported in patients with macrovascular disease. We investigated whether sHSP27 levels were associated with micro- and macrovascular complications in type 1 diabetic patients. RESEARCH DESIGN AND METHODS-A cross-sectional, nested, case-control study from the EURODLAB Prospective Complications Study of 531 type 1 diabetic patients was performed. Case subjects (n = 363) were defined as those with one or more complications of diabetes; control subjects (n = 168) were defined as those with no evidence of any complication. We measured sHSP27 levels and investigated their associations with diabetes complications. RESULTS-Mean sHSP27 levels were significantly higher in case subjects with distal symmetrical polyneuropathy (DSP) than in control subjects, even after adjustment for age and albumin excretion rate (AER) (785.9 vs. 574.7 pg/ml, P = 0.03). In logistic regression analysis, sHSP27 levels in the upper quartile were associated with a twofold increased odds ratio (OR) of DSP, independently of conventional risk factors, markers of inflammation, and AER (OR 2.41 [959/o CI 1.11-5.24]). CONCLUSIONS-In this large cohort of type 1 diabetic subjects, we found an independent association between sHSP27 and DSP. This suggests that sHSP27 levels may be a novel marker for diabetic neuropathy.",
author = "G. Gruden and G. Bruno and N. Cahturvedi and D. Burt and C.G. Schalkwijk and S. Pinach and C.D.A. Stehouwer and D.R. Witte and J.F. Fuller and {Cavallo Perin}, P.",
year = "2008",
month = "1",
day = "1",
doi = "10.2337/db08-0009",
language = "English",
volume = "57",
pages = "1966--70",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",

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EURODIAB Prospective Complications Study Group Serum HSP27 and diabetes complications in the Eurodiab Prospective Complications Study: a novel circulating marker for diabetic neuropathy. / Gruden, G.; Bruno, G.; Cahturvedi, N.; Burt, D.; Schalkwijk, C.G.; Pinach, S.; Stehouwer, C.D.A.; Witte, D.R.; Fuller, J.F.; Cavallo Perin, P.

In: Diabetes, Vol. 57, 01.01.2008, p. 1966-70.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - EURODIAB Prospective Complications Study Group Serum HSP27 and diabetes complications in the Eurodiab Prospective Complications Study: a novel circulating marker for diabetic neuropathy

AU - Gruden, G.

AU - Bruno, G.

AU - Cahturvedi, N.

AU - Burt, D.

AU - Schalkwijk, C.G.

AU - Pinach, S.

AU - Stehouwer, C.D.A.

AU - Witte, D.R.

AU - Fuller, J.F.

AU - Cavallo Perin, P.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - OBJECTIVE-Heat shock protein 27 (HSP27) is a member of the small heat shock protein family of proteins. HSP27 expression is enhanced in target tissues of diabetic microvascular complications, and changes in circulating serum HSP27 levels (sHSP27) have been reported in patients with macrovascular disease. We investigated whether sHSP27 levels were associated with micro- and macrovascular complications in type 1 diabetic patients. RESEARCH DESIGN AND METHODS-A cross-sectional, nested, case-control study from the EURODLAB Prospective Complications Study of 531 type 1 diabetic patients was performed. Case subjects (n = 363) were defined as those with one or more complications of diabetes; control subjects (n = 168) were defined as those with no evidence of any complication. We measured sHSP27 levels and investigated their associations with diabetes complications. RESULTS-Mean sHSP27 levels were significantly higher in case subjects with distal symmetrical polyneuropathy (DSP) than in control subjects, even after adjustment for age and albumin excretion rate (AER) (785.9 vs. 574.7 pg/ml, P = 0.03). In logistic regression analysis, sHSP27 levels in the upper quartile were associated with a twofold increased odds ratio (OR) of DSP, independently of conventional risk factors, markers of inflammation, and AER (OR 2.41 [959/o CI 1.11-5.24]). CONCLUSIONS-In this large cohort of type 1 diabetic subjects, we found an independent association between sHSP27 and DSP. This suggests that sHSP27 levels may be a novel marker for diabetic neuropathy.

AB - OBJECTIVE-Heat shock protein 27 (HSP27) is a member of the small heat shock protein family of proteins. HSP27 expression is enhanced in target tissues of diabetic microvascular complications, and changes in circulating serum HSP27 levels (sHSP27) have been reported in patients with macrovascular disease. We investigated whether sHSP27 levels were associated with micro- and macrovascular complications in type 1 diabetic patients. RESEARCH DESIGN AND METHODS-A cross-sectional, nested, case-control study from the EURODLAB Prospective Complications Study of 531 type 1 diabetic patients was performed. Case subjects (n = 363) were defined as those with one or more complications of diabetes; control subjects (n = 168) were defined as those with no evidence of any complication. We measured sHSP27 levels and investigated their associations with diabetes complications. RESULTS-Mean sHSP27 levels were significantly higher in case subjects with distal symmetrical polyneuropathy (DSP) than in control subjects, even after adjustment for age and albumin excretion rate (AER) (785.9 vs. 574.7 pg/ml, P = 0.03). In logistic regression analysis, sHSP27 levels in the upper quartile were associated with a twofold increased odds ratio (OR) of DSP, independently of conventional risk factors, markers of inflammation, and AER (OR 2.41 [959/o CI 1.11-5.24]). CONCLUSIONS-In this large cohort of type 1 diabetic subjects, we found an independent association between sHSP27 and DSP. This suggests that sHSP27 levels may be a novel marker for diabetic neuropathy.

U2 - 10.2337/db08-0009

DO - 10.2337/db08-0009

M3 - Article

VL - 57

SP - 1966

EP - 1970

JO - Diabetes

JF - Diabetes

SN - 0012-1797

ER -