ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer

Felipe A. Calvo*, Claudio V. Sole, Harm J. Rutten, Philip Poortmans, Jose M. Asencio, Javier Serrano, Javier Aristu, Falk Roeder, Wim J. Dries

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)

Abstract

Carcinoma of the rectum is a heterogeneous disease. The clinical spectrum identifies a subset of patients with locally advanced tumours that are close to or involve adjoining structures, such as the sacrum, pelvic sidewalls, prostate or bladder. Within this group of patients categorized as "locally advanced", there is also variability in the extent of disease with no uniform definition of resectability. A practice-oriented definition of a locally advanced tumour is a tumour that cannot be resected without leaving microscopic or gross residual disease at the resection site. Since these patients do poorly with surgery alone, irradiation and chemotherapy have been added to improve the outcome. Intraoperative irradiation (IORT) is a component of local treatment intensification with favourable results in this subgroup of patients.

International guidelines (National Comprehensive Cancer Network (NCCN) guidelines) currently recommend the use of IORT for rectal cancer resectable with very close or positive margins, especially for T4 and recurrent cancers.

We report the ESTRO-ACROP (European Society for Radiotherapy and Oncology Advisory Committee on Radiation Oncology Practice) recommendations for performing IORT in primary locally advanced rectal cancer. (c) 2020 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalClinical and Translational Radiation Oncology
Volume25
DOIs
Publication statusPublished - Nov 2020

Keywords

  • Rectal cancer
  • Locally advanced disease
  • Intraoperative radiotherapy
  • Radical surgery
  • Electron beam
  • Neoadjuvant treatment
  • ELECTRON BOOST RADIOTHERAPY
  • TOTAL MESORECTAL EXCISION
  • COLORECTAL-CANCER
  • MULTIMODALITY TREATMENT
  • ADJUVANT CHEMOTHERAPY
  • POOLED ANALYSIS
  • CHEMORADIATION
  • COMBINATION
  • RECURRENCE
  • RESECTION

Cite this