ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in locally recurrent rectal cancer

Felipe A. Calvo; Claudio V. Sole; Harm J. Rutten; Wim J. Dries; Miguel A. Lozano; Mauricio Cambeiro; Philip Poortmans; Luis Gonzalez-Bayon

doi:10.1016/j.ctro.2020.06.007

ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in locally recurrent rectal cancer

Felipe A. Calvo^*, Claudio V. Sole, Harm J. Rutten, Wim J. Dries, Miguel A. Lozano, Mauricio Cambeiro, Philip Poortmans, Luis Gonzalez-Bayon

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Multimodal strategies have been implemented for locally recurrent rectal cancer scheduled for complete surgical resection. Irradiation and systemic therapy have been added to improve the oncological outcome, as surgery alone was associated with a poor prognosis. Intraoperative irradiation (IORT) is a component of irradiation intensification. Long-term cancer control and a higher survival rate were consistently reported in patients who had IORT as a component of their multidisciplinary treatment. The experience reported by expert IORT groups is reviewed and recommendations to guide clinical practice are explained in detail. (c) 2020 Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.

Original language	English
Pages (from-to)	41-48
Number of pages	8
Journal	Clinical and Translational Radiation Oncology
Volume	24
DOIs	https://doi.org/10.1016/j.ctro.2020.06.007
Publication status	Published - Sept 2020

Keywords

Rectal cancer
Recurrent disease
Oligo-recurrence
Intraoperative radiotherapy
Rescue surgery
Electron beam
SURGICAL RESECTION
MULTIMODALITY TREATMENT
PELVIC RECURRENCE
RADIOTHERAPY IORT
ELECTRON-BEAM
SURGERY
BRACHYTHERAPY
CHEMORADIATION
REIRRADIATION
IRRADIATION

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Cite this

@article{5e736beac5014024ae52d1d203e34b09,

title = "ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in locally recurrent rectal cancer",

abstract = "Multimodal strategies have been implemented for locally recurrent rectal cancer scheduled for complete surgical resection. Irradiation and systemic therapy have been added to improve the oncological outcome, as surgery alone was associated with a poor prognosis. Intraoperative irradiation (IORT) is a component of irradiation intensification. Long-term cancer control and a higher survival rate were consistently reported in patients who had IORT as a component of their multidisciplinary treatment. The experience reported by expert IORT groups is reviewed and recommendations to guide clinical practice are explained in detail. (c) 2020 Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.",

keywords = "Rectal cancer, Recurrent disease, Oligo-recurrence, Intraoperative radiotherapy, Rescue surgery, Electron beam, SURGICAL RESECTION, MULTIMODALITY TREATMENT, PELVIC RECURRENCE, RADIOTHERAPY IORT, ELECTRON-BEAM, SURGERY, BRACHYTHERAPY, CHEMORADIATION, REIRRADIATION, IRRADIATION",

author = "Calvo, {Felipe A.} and Sole, {Claudio V.} and Rutten, {Harm J.} and Dries, {Wim J.} and Lozano, {Miguel A.} and Mauricio Cambeiro and Philip Poortmans and Luis Gonzalez-Bayon",

note = "Funding Information: Intraoperative radiotherapy (IORT) is a multidisciplinary oncological activity requiring a demanding the integration of individual technical quality and team work coordination. The authors of this guideline acknowledge the remarkable contribution of all the health professionals involved in the care of patient candidates to IORT procedures. Authors are grateful to reviewers Robert Krempien, Philipp Scherer, Alexandra Stewart, Dirk Verellen for their useful and constructive comments and to Eralda Azizaj (ESTRO staff member responsible for the work of ACROP) for facilitating the review and journal submission process. Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = sep,

doi = "10.1016/j.ctro.2020.06.007",

language = "English",

volume = "24",

pages = "41--48",

journal = "Clinical and Translational Radiation Oncology",

issn = "2405-6308",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in locally recurrent rectal cancer

AU - Calvo, Felipe A.

AU - Sole, Claudio V.

AU - Rutten, Harm J.

AU - Dries, Wim J.

AU - Lozano, Miguel A.

AU - Cambeiro, Mauricio

AU - Poortmans, Philip

AU - Gonzalez-Bayon, Luis

N1 - Funding Information: Intraoperative radiotherapy (IORT) is a multidisciplinary oncological activity requiring a demanding the integration of individual technical quality and team work coordination. The authors of this guideline acknowledge the remarkable contribution of all the health professionals involved in the care of patient candidates to IORT procedures. Authors are grateful to reviewers Robert Krempien, Philipp Scherer, Alexandra Stewart, Dirk Verellen for their useful and constructive comments and to Eralda Azizaj (ESTRO staff member responsible for the work of ACROP) for facilitating the review and journal submission process. Publisher Copyright: © 2020

PY - 2020/9

Y1 - 2020/9

N2 - Multimodal strategies have been implemented for locally recurrent rectal cancer scheduled for complete surgical resection. Irradiation and systemic therapy have been added to improve the oncological outcome, as surgery alone was associated with a poor prognosis. Intraoperative irradiation (IORT) is a component of irradiation intensification. Long-term cancer control and a higher survival rate were consistently reported in patients who had IORT as a component of their multidisciplinary treatment. The experience reported by expert IORT groups is reviewed and recommendations to guide clinical practice are explained in detail. (c) 2020 Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.

AB - Multimodal strategies have been implemented for locally recurrent rectal cancer scheduled for complete surgical resection. Irradiation and systemic therapy have been added to improve the oncological outcome, as surgery alone was associated with a poor prognosis. Intraoperative irradiation (IORT) is a component of irradiation intensification. Long-term cancer control and a higher survival rate were consistently reported in patients who had IORT as a component of their multidisciplinary treatment. The experience reported by expert IORT groups is reviewed and recommendations to guide clinical practice are explained in detail. (c) 2020 Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.

KW - Rectal cancer

KW - Recurrent disease

KW - Oligo-recurrence

KW - Intraoperative radiotherapy

KW - Rescue surgery

KW - Electron beam

KW - SURGICAL RESECTION

KW - MULTIMODALITY TREATMENT

KW - PELVIC RECURRENCE

KW - RADIOTHERAPY IORT

KW - ELECTRON-BEAM

KW - SURGERY

KW - BRACHYTHERAPY

KW - CHEMORADIATION

KW - REIRRADIATION

KW - IRRADIATION

U2 - 10.1016/j.ctro.2020.06.007

DO - 10.1016/j.ctro.2020.06.007

M3 - Article

C2 - 32613091

SN - 2405-6308

VL - 24

SP - 41

EP - 48

JO - Clinical and Translational Radiation Oncology

JF - Clinical and Translational Radiation Oncology

ER -