ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease

M L Mearin; D Agardh; H Antunes; A Al-Toma; R Auricchio; G Castillejo; C Catassi; C Ciacci; V Discepolo; J Dolinsek; E Donat; P Gillett; S Guandalini; S Husby; S Koletzko; T Koltai; I R Korponay-Szabó; K Kurppa; E Lionetti; K Mårild; E Martinez Ojinaga; C Meijer; C Monachesi; I Polanco; A Popp; M Roca; A Rodriguez-Herrera; R Shamir; K Stordal; R Troncone; F Valitutti; A Vreugdenhil; M Wessels; P Whiting; ESPGHAN Special Interest Group on Celiac Disease

doi:10.1097/mpg.0000000000003540

ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease

M L Mearin^*
, D Agardh
, H Antunes
, A Al-Toma
, R Auricchio
, G Castillejo
, C Catassi
, C Ciacci
, V Discepolo
, J Dolinsek
, E Donat
, P Gillett
, S Guandalini
, S Husby
, S Koletzko
, T Koltai
, I R Korponay-Szabó
, K Kurppa
, E Lionetti
, K Mårild

E Martinez Ojinaga, C Meijer, C Monachesi, I Polanco, A Popp, M Roca, A Rodriguez-Herrera, R Shamir, K Stordal, R Troncone, F Valitutti, A Vreugdenhil, M Wessels, P Whiting, ESPGHAN Special Interest Group on Celiac Disease

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

AIM: To gather the current evidence and to offer recommendations for follow-up and management.

METHODS: The Special Interest Group on Coeliac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010 - March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all co-authors. Recommendations were voted upon: joint agreement was set as at least 85%.

RESULTS: Publications (n=2775) were identified and 164 were included. Using evidence and/or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anaemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential coeliac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from paediatric to adult health-care.

CONCLUSIONS: We offer recommendations to improve follow-up of children and adolescents with coeliac disease and highlight gaps that should be investigated to further improve management.

Original language	English
Pages (from-to)	369-386
Number of pages	18
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	75
Issue number	3
Early online date	27 Jun 2022
DOIs	https://doi.org/10.1097/mpg.0000000000003540
Publication status	Published - Sept 2022

Keywords

BONE-MINERAL DENSITY
DOUBLE-BLIND
EUROPEAN-SOCIETY
GLUTEN-FREE DIET
HEPATITIS-B-VACCINE
IMMUNE-RESPONSE
LARAZOTIDE ACETATE
MUCOSAL RECOVERY
QUALITY-OF-LIFE
THYROID-DISEASE
celiac disease
children and adolescents
follow-up
position paper European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN)

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10.1097/mpg.0000000000003540

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Mearin, M. L., Agardh, D., Antunes, H., Al-Toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., Donat, E., Gillett, P., Guandalini, S., Husby, S., Koletzko, S., Koltai, T., Korponay-Szabó, I. R., Kurppa, K., Lionetti, E., ... ESPGHAN Special Interest Group on Celiac Disease (2022). ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. Journal of Pediatric Gastroenterology and Nutrition, 75(3), 369-386. https://doi.org/10.1097/mpg.0000000000003540

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abstract = "AIM: To gather the current evidence and to offer recommendations for follow-up and management.METHODS: The Special Interest Group on Coeliac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010 - March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all co-authors. Recommendations were voted upon: joint agreement was set as at least 85\%.RESULTS: Publications (n=2775) were identified and 164 were included. Using evidence and/or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anaemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential coeliac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from paediatric to adult health-care.CONCLUSIONS: We offer recommendations to improve follow-up of children and adolescents with coeliac disease and highlight gaps that should be investigated to further improve management.",

keywords = "BONE-MINERAL DENSITY, DOUBLE-BLIND, EUROPEAN-SOCIETY, GLUTEN-FREE DIET, HEPATITIS-B-VACCINE, IMMUNE-RESPONSE, LARAZOTIDE ACETATE, MUCOSAL RECOVERY, QUALITY-OF-LIFE, THYROID-DISEASE, celiac disease, children and adolescents, follow-up, position paper European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN)",

author = "Mearin, \{M L\} and D Agardh and H Antunes and A Al-Toma and R Auricchio and G Castillejo and C Catassi and C Ciacci and V Discepolo and J Dolinsek and E Donat and P Gillett and S Guandalini and S Husby and S Koletzko and T Koltai and Korponay-Szab{\'o}, \{I R\} and K Kurppa and E Lionetti and K M{\aa}rild and \{Martinez Ojinaga\}, E and C Meijer and C Monachesi and I Polanco and A Popp and M Roca and A Rodriguez-Herrera and R Shamir and K Stordal and R Troncone and F Valitutti and A Vreugdenhil and M Wessels and P Whiting and \{ESPGHAN Special Interest Group on Celiac Disease\}",

note = "Copyright {\textcopyright} 2022 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.",

year = "2022",

month = sep,

doi = "10.1097/mpg.0000000000003540",

language = "English",

volume = "75",

pages = "369--386",

journal = "Journal of Pediatric Gastroenterology and Nutrition",

issn = "0277-2116",

publisher = "John Wiley \& Sons Inc.",

number = "3",

}

Mearin, ML, Agardh, D, Antunes, H, Al-Toma, A, Auricchio, R, Castillejo, G, Catassi, C, Ciacci, C, Discepolo, V, Dolinsek, J, Donat, E, Gillett, P, Guandalini, S, Husby, S, Koletzko, S, Koltai, T, Korponay-Szabó, IR, Kurppa, K, Lionetti, E, Mårild, K, Martinez Ojinaga, E, Meijer, C, Monachesi, C, Polanco, I, Popp, A, Roca, M, Rodriguez-Herrera, A, Shamir, R, Stordal, K, Troncone, R, Valitutti, F, Vreugdenhil, A, Wessels, M, Whiting, P & ESPGHAN Special Interest Group on Celiac Disease 2022, 'ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease', Journal of Pediatric Gastroenterology and Nutrition, vol. 75, no. 3, pp. 369-386. https://doi.org/10.1097/mpg.0000000000003540

TY - JOUR

T1 - ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease

AU - Mearin, M L

AU - Agardh, D

AU - Antunes, H

AU - Al-Toma, A

AU - Auricchio, R

AU - Castillejo, G

AU - Catassi, C

AU - Ciacci, C

AU - Discepolo, V

AU - Dolinsek, J

AU - Donat, E

AU - Gillett, P

AU - Guandalini, S

AU - Husby, S

AU - Koletzko, S

AU - Koltai, T

AU - Korponay-Szabó, I R

AU - Kurppa, K

AU - Lionetti, E

AU - Mårild, K

AU - Martinez Ojinaga, E

AU - Meijer, C

AU - Monachesi, C

AU - Polanco, I

AU - Popp, A

AU - Roca, M

AU - Rodriguez-Herrera, A

AU - Shamir, R

AU - Stordal, K

AU - Troncone, R

AU - Valitutti, F

AU - Vreugdenhil, A

AU - Wessels, M

AU - Whiting, P

AU - ESPGHAN Special Interest Group on Celiac Disease

PY - 2022/9

Y1 - 2022/9

N2 - AIM: To gather the current evidence and to offer recommendations for follow-up and management.METHODS: The Special Interest Group on Coeliac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010 - March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all co-authors. Recommendations were voted upon: joint agreement was set as at least 85%.RESULTS: Publications (n=2775) were identified and 164 were included. Using evidence and/or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anaemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential coeliac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from paediatric to adult health-care.CONCLUSIONS: We offer recommendations to improve follow-up of children and adolescents with coeliac disease and highlight gaps that should be investigated to further improve management.

AB - AIM: To gather the current evidence and to offer recommendations for follow-up and management.METHODS: The Special Interest Group on Coeliac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow-up care. A literature search (January 2010 - March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all co-authors. Recommendations were voted upon: joint agreement was set as at least 85%.RESULTS: Publications (n=2775) were identified and 164 were included. Using evidence and/or expert opinion, 37 recommendations were formulated on: The need to perform follow-up, its frequency and what should be assessed, how to assess adherence to the gluten-free diet, when to expect catch-up growth, how to treat anaemia, how to approach persistent high serum levels of antibodies against tissue-transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential coeliac disease, which professionals should perform follow-up, how to improve the communication to patients and their parents/caregivers and transition from paediatric to adult health-care.CONCLUSIONS: We offer recommendations to improve follow-up of children and adolescents with coeliac disease and highlight gaps that should be investigated to further improve management.

KW - BONE-MINERAL DENSITY

KW - DOUBLE-BLIND

KW - EUROPEAN-SOCIETY

KW - GLUTEN-FREE DIET

KW - HEPATITIS-B-VACCINE

KW - IMMUNE-RESPONSE

KW - LARAZOTIDE ACETATE

KW - MUCOSAL RECOVERY

KW - QUALITY-OF-LIFE

KW - THYROID-DISEASE

KW - celiac disease

KW - children and adolescents

KW - follow-up

KW - position paper European Society of Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN)

U2 - 10.1097/mpg.0000000000003540

DO - 10.1097/mpg.0000000000003540

M3 - Article

C2 - 35758521

SN - 0277-2116

VL - 75

SP - 369

EP - 386

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

IS - 3

ER -

ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease

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