Esophageal Cancer After Bariatric Surgery: Increasing Prevalence and Treatment Strategies

V.D. Plat, A. Kasteleijn, J.W.M. Greve, M.D.P. Luyer, S.S. Gisbertz, A. Demirkiran, F. Daams*

*Corresponding author for this work

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12 Citations (Web of Science)


Purpose The number of bariatric procedures has increased exponentially over the last 20 years. On the background of ever-increasing incidence of esophageal malignancies, the altered anatomy after bariatric surgery poses challenges in treatment of these cancers. In this study, an epidemiological estimate is presented for the future magnitude of this problem and treatment options are described in a retrospective multicenter cohort.Methods The number of bariatric procedures, esophageal cancer incidence, and mortality rates of the general population were used for epidemiological estimates. A retrospective multicenter cohort was composed; patients were treated in three large oncological centers with a high upper gastrointestinal cancer caseload. Consecutive patients with preceding bariatric surgery who developed esophageal cancer between 2014 and 2019 were included.Results Approximately 3200 out of 6.4 million post bariatric surgery patients are estimated to have developed esophageal cancer between 1998 and 2018 worldwide. In a multicenter cohort, 15 patients with esophageal cancer or Barrett's esophagus and preceding bariatric surgery were identified. The majority of patients had a history of Roux-en-Y gastric bypass (46.7%) and had an adenocarcinoma of the distal esophagus (60%). Seven patients received curative surgical treatment, five of whom are still alive at last follow-up (median follow-up 2 years, no loss to follow-up).Conclusion Based on worldwide data, esophageal cancer development following bariatric surgery has increased over the past decades. Treatment of patients with esophageal cancer after bariatric surgery is challenging and requires a highly individualized approach in which optimal treatment and anatomical limitations are carefully balanced.
Original languageEnglish
Pages (from-to)4954-4962
Number of pages9
JournalObesity Surgery
Issue number11
Early online date7 Sept 2021
Publication statusPublished - Nov 2021


  • Esophageal cancer
  • Bariatric surgery
  • Esophagectomy
  • Treatment
  • RISK

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