Erythrocyte glutathione S transferase as a marker of oxidative stress at birth.

V.M. Neefjes, C.T.A. Evelo, L.G.M. Baars, C.E. Blanco

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Department of Paediatrics Academic Hospital Maastricht PO Box 5800 6202 AZ Maastricht The Netherlands.

AIMS: To determine the level of oxidative stress and cell damage as a result of exposure to O(2) at birth. METHODS: Using glutathione S transferase (GST) as an indicator of oxidative stress, GST activity in cord blood was compared with that in samples taken three hours after birth. Twenty four prematurely born infants and eight full term infants were studied. To test whether stronger effects occur under less favourable conditions, the neonates were divided in three groups: healthy premature; sick premature; and healthy full term infants. RESULTS: GST activity three hours after birth was significantly decreased compared with that at birth in all three groups tested. There were no significant differences in the magnitude of this effect among the three groups. CONCLUSIONS: These results indicate that a sudden increase in oxygenation exposes the neonate to oxidative stress. Measurement of GST activity might be useful for the evaluation of protective treatment in trials considering antioxidant strategies.
Original languageEnglish
Pages (from-to)F130-F133
Number of pages4
JournalArchives of Disease in Childhood
Volume81
Issue number2
DOIs
Publication statusPublished - 1 Jan 1999

Cite this