Erratum to: Parent-of-origin-specific signatures of de novo mutations

Jakob M. Goldmann, Wendy S.W. Wong, Michele Pinelli, Terry Farrah, Dale Bodian, Anna B. Stittrich, Gustavo Glusman, Lisenka E.L.M. Vissers, Alexander Hoischen, Jared C. Roach, Joseph G. Vockley, Joris A. Veltman, Benjamin D. Solomon, Christian Gilissen, John E. Niederhuber*

*Corresponding author for this work

Research output: Contribution to journalErratum / corrigendum / retractionsAcademic

Abstract

In the version of this article published, the P values for the enrichment of single mutation categories were inadvertently not corrected for multiple testing. After multiple-testing correction, only two of the six mutation categories mentioned are still statistically significant. To reflect this, the text “More specifically, paternally derived DNMs are enriched in transitions in A[.]G contexts, especially ACG>ATG and ATG>ACG (Bonferroni-corrected P = 1.3 × 10 -2 and P = 1 × 10 -3 , respectively). Additionally, we observed overrepresentation of ATA>ACA mutations (Bonferroni-corrected P = 4.28 × 10 -2 ) for DNMs of paternal origin. Among maternally derived DNMs, CCA>CTA, GCA>GTA and TCT>TGT mutations were significantly overrepresented (Bonferroni-corrected P = 4 × 10 -4 , P = 5 × 10 -4 , P = 1 × 10 -3 , respectively)” should read “More specifically, CCA>CTA and GCA>GTA mutations were significantly overenriched on the maternal allele (Bonferroni-corrected P = 0.0192 and P = 0.048, respectively).” Additionally, the last sentence to the legend for Fig. 3b should read “Green boxes highlight the mutation categories that differ significantly” instead of “Green boxes highlight the mutation categories that differ more than 1% of mutation load with a bootstrapping P value <0.05.” Corrected versions of Fig. 3b and Supplementary Table 25 appear with the Author Correction.
Original languageEnglish
Pages (from-to)1615
JournalNature Genetics
Volume50
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

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  • Parent-of-origin-specific signatures of de novo mutations

    Goldmann, J. M., Wong, W. S. W., Pinelli, M., Farrah, T., Bodian, D., Stittrich, A. B., Glusman, G., Vissers, L. E. L. M., Hoischen, A., Roach, J. C., Vockley, J. G., Veltman, J. A., Solomon, B. D., Gilissen, C. & Niederhuber, J. E., Aug 2016, In: Nature Genetics. 48, 8, p. 935–939

    Research output: Contribution to journalArticleAcademicpeer-review

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