(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Amela Jusic; Konstantinos Stellos; Lino Ferreira; Andrew H Baker; Yvan Devaux

doi:10.1016/j.jmccpl.2022.100013

(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Amela Jusic, Konstantinos Stellos, Lino Ferreira, Andrew H Baker, Yvan Devaux^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS-CoV-2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.

Original language	English
Article number	100013
Number of pages	9
Journal	Journal of Molecular and Cellular Cardiology Plus
Volume	1
DOIs	https://doi.org/10.1016/j.jmccpl.2022.100013
Publication status	Published - Sept 2022

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Cite this

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title = "(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19",

abstract = "Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS-CoV-2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.",

author = "Amela Jusic and Konstantinos Stellos and Lino Ferreira and Baker, {Andrew H} and Yvan Devaux",

note = "{\textcopyright} 2022 The Authors. ",

year = "2022",

month = sep,

doi = "10.1016/j.jmccpl.2022.100013",

language = "English",

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journal = "Journal of Molecular and Cellular Cardiology Plus",

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T1 - (Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

AU - Jusic, Amela

AU - Stellos, Konstantinos

AU - Ferreira, Lino

AU - Baker, Andrew H

AU - Devaux, Yvan

PY - 2022/9

Y1 - 2022/9

N2 - Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS-CoV-2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.

AB - Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS-CoV-2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.

U2 - 10.1016/j.jmccpl.2022.100013

DO - 10.1016/j.jmccpl.2022.100013

M3 - (Systematic) Review article

C2 - 36164464

SN - 2772-9761

VL - 1

JO - Journal of Molecular and Cellular Cardiology Plus

JF - Journal of Molecular and Cellular Cardiology Plus

M1 - 100013

ER -