Abstract
Background Aberrant DNA methylation may promote prostate carcinogenesis. We investigated epigenome-wide DNA methylation profiles in prostate cancer (PCa) compared to adjacent benign tissue to identify differentially methylated CpG sites. MethodsThe study included paired PCa and adjacent benign tissue samples from 20 radical prostatectomy patients. Epigenetic profiling was done using the Infinium HumanMethylation450 BeadChip. Linear models that accounted for the paired study design and False Discovery Rate Q-values were used to evaluate differential CpG methylation. mRNA expression levels of the genes with the most differentially methylated CpG sites were analyzed. ResultsIn total, 2,040 differentially methylated CpG sites were identified in PCa versus adjacent benign tissue (Q-value
Original language | English |
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Pages (from-to) | 1941-1950 |
Journal | Prostate |
Volume | 75 |
Issue number | 16 |
DOIs | |
Publication status | Published - 1 Dec 2015 |
Keywords
- prostate cancer
- DNA methylation
- mRNA expression
- tumor
- benign