Epigenetics and microRNAs in cardiovascular diseases

Robin M. W. Colpaert; Martina Calore

doi:10.1016/j.ygeno.2020.12.042

Epigenetics and microRNAs in cardiovascular diseases

Robin M. W. Colpaert, Martina Calore^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Cardiovascular diseases are among the leading causes of mortality worldwide. Besides environmental and genetic changes, these disorders can be influenced by processes which do not affect DNA sequence yet still play an important role in gene expression and which can be inherited. These so-called 'epigenetic' changes include DNA methylation, histone modifications, and ATP-dependent chromatin remodeling enzymes, which influence chromatin remodeling and gene expression. Next to these, microRNAs are non-coding RNA molecules that silence genes post-transcriptionally. Both epigenetic factors and microRNAs are known to influence cardiac development and homeostasis, in an individual fashion but also in a complex regulatory network. In this review, we will discuss how epigenetic factors and microRNAs interact with each other and how together they can influence cardiovascular diseases.

Original language	English
Pages (from-to)	540-551
Number of pages	12
Journal	Genomics
Volume	113
Issue number	2
DOIs	https://doi.org/10.1016/j.ygeno.2020.12.042
Publication status	Published - Mar 2021

Keywords

Heart
miRNAs
Epigenetics
Cardiovascular diseases

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10.1016/j.ygeno.2020.12.042Licence: CC BY

Cite this

@article{48928d579dfd4102a0f3c09f998fb681,

title = "Epigenetics and microRNAs in cardiovascular diseases",

abstract = "Cardiovascular diseases are among the leading causes of mortality worldwide. Besides environmental and genetic changes, these disorders can be influenced by processes which do not affect DNA sequence yet still play an important role in gene expression and which can be inherited. These so-called 'epigenetic' changes include DNA methylation, histone modifications, and ATP-dependent chromatin remodeling enzymes, which influence chromatin remodeling and gene expression. Next to these, microRNAs are non-coding RNA molecules that silence genes post-transcriptionally. Both epigenetic factors and microRNAs are known to influence cardiac development and homeostasis, in an individual fashion but also in a complex regulatory network. In this review, we will discuss how epigenetic factors and microRNAs interact with each other and how together they can influence cardiovascular diseases.",

keywords = "Heart, miRNAs, Epigenetics, Cardiovascular diseases",

author = "Colpaert, {Robin M. W.} and Martina Calore",

note = "Funding Information: We acknowledge the support from the DCVA, an initiative with support from the Dutch Heart Foundation, DCVA2017-2018 ARENA-PRIME. Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

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AU - Calore, Martina

PY - 2021/3

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AB - Cardiovascular diseases are among the leading causes of mortality worldwide. Besides environmental and genetic changes, these disorders can be influenced by processes which do not affect DNA sequence yet still play an important role in gene expression and which can be inherited. These so-called 'epigenetic' changes include DNA methylation, histone modifications, and ATP-dependent chromatin remodeling enzymes, which influence chromatin remodeling and gene expression. Next to these, microRNAs are non-coding RNA molecules that silence genes post-transcriptionally. Both epigenetic factors and microRNAs are known to influence cardiac development and homeostasis, in an individual fashion but also in a complex regulatory network. In this review, we will discuss how epigenetic factors and microRNAs interact with each other and how together they can influence cardiovascular diseases.

KW - Heart

KW - miRNAs

KW - Epigenetics

KW - Cardiovascular diseases

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DO - 10.1016/j.ygeno.2020.12.042

M3 - (Systematic) Review article

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