Abstract
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurode-generative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 158-170 |
| Number of pages | 13 |
| Journal | Journal of Neurochemistry |
| Volume | 143 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Oct 2017 |
Keywords
- Alzheimer's disease
- DNA hydroxymethylation
- DNA methylation
- epigenetic
- epigenome-wide association study
- genetic
- MESSENGER-RNA EXPRESSION
- AMYOTROPHIC-LATERAL-SCLEROSIS
- PROMOTER METHYLATION LEVELS
- SUPERIOR TEMPORAL GYRUS
- PRECURSOR PROTEIN GENE
- ALPHA-SYNUCLEIN GENE
- HUMAN BASAL GANGLIA
- PARKINSONS-DISEASE
- LEUKOCYTE DNA
- MAMMALIAN DNA
Fingerprint
Dive into the research topics of 'Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver