Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

Janou A. Y. Roubroeks; Rebecca G. Smith; Daniel L. A. van den Hove; Katie Lunnon

doi:10.1111/jnc.14148

Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

Janou A. Y. Roubroeks, Rebecca G. Smith, Daniel L. A. van den Hove, Katie Lunnon^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurode-generative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.

Original language	English
Pages (from-to)	158-170
Number of pages	13
Journal	Journal of Neurochemistry
Volume	143
Issue number	2
DOIs	https://doi.org/10.1111/jnc.14148
Publication status	Published - Oct 2017

Keywords

Alzheimer's disease
DNA hydroxymethylation
DNA methylation
epigenetic
epigenome-wide association study
genetic
MESSENGER-RNA EXPRESSION
AMYOTROPHIC-LATERAL-SCLEROSIS
PROMOTER METHYLATION LEVELS
SUPERIOR TEMPORAL GYRUS
PRECURSOR PROTEIN GENE
ALPHA-SYNUCLEIN GENE
HUMAN BASAL GANGLIA
PARKINSONS-DISEASE
LEUKOCYTE DNA
MAMMALIAN DNA

Access to Document

10.1111/jnc.14148

Cite this

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title = "Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases",

abstract = "Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurode-generative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.",

keywords = "Alzheimer's disease, DNA hydroxymethylation, DNA methylation, epigenetic, epigenome-wide association study, genetic, MESSENGER-RNA EXPRESSION, AMYOTROPHIC-LATERAL-SCLEROSIS, PROMOTER METHYLATION LEVELS, SUPERIOR TEMPORAL GYRUS, PRECURSOR PROTEIN GENE, ALPHA-SYNUCLEIN GENE, HUMAN BASAL GANGLIA, PARKINSONS-DISEASE, LEUKOCYTE DNA, MAMMALIAN DNA",

author = "Roubroeks, {Janou A. Y.} and Smith, {Rebecca G.} and {van den Hove}, {Daniel L. A.} and Katie Lunnon",

year = "2017",

month = oct,

doi = "10.1111/jnc.14148",

language = "English",

volume = "143",

pages = "158--170",

journal = "Journal of Neurochemistry",

issn = "0022-3042",

publisher = "Wiley",

number = "2",

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T1 - Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

AU - Roubroeks, Janou A. Y.

AU - Smith, Rebecca G.

AU - van den Hove, Daniel L. A.

AU - Lunnon, Katie

PY - 2017/10

Y1 - 2017/10

N2 - Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurode-generative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.

AB - Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurode-generative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.

KW - Alzheimer's disease

KW - DNA hydroxymethylation

KW - DNA methylation

KW - epigenetic

KW - epigenome-wide association study

KW - genetic

KW - MESSENGER-RNA EXPRESSION

KW - AMYOTROPHIC-LATERAL-SCLEROSIS

KW - PROMOTER METHYLATION LEVELS

KW - SUPERIOR TEMPORAL GYRUS

KW - PRECURSOR PROTEIN GENE

KW - ALPHA-SYNUCLEIN GENE

KW - HUMAN BASAL GANGLIA

KW - PARKINSONS-DISEASE

KW - LEUKOCYTE DNA

KW - MAMMALIAN DNA

U2 - 10.1111/jnc.14148

DO - 10.1111/jnc.14148

M3 - (Systematic) Review article

SN - 0022-3042

VL - 143

SP - 158

EP - 170

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

IS - 2

ER -