Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

Janou A. Y. Roubroeks, Rebecca G. Smith, Daniel L. A. van den Hove, Katie Lunnon*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

48 Citations (Web of Science)

Abstract

Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurode-generative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.

Original languageEnglish
Pages (from-to)158-170
Number of pages13
JournalJournal of Neurochemistry
Volume143
Issue number2
DOIs
Publication statusPublished - Oct 2017

Keywords

  • Alzheimer's disease
  • DNA hydroxymethylation
  • DNA methylation
  • epigenetic
  • epigenome-wide association study
  • genetic
  • MESSENGER-RNA EXPRESSION
  • AMYOTROPHIC-LATERAL-SCLEROSIS
  • PROMOTER METHYLATION LEVELS
  • SUPERIOR TEMPORAL GYRUS
  • PRECURSOR PROTEIN GENE
  • ALPHA-SYNUCLEIN GENE
  • HUMAN BASAL GANGLIA
  • PARKINSONS-DISEASE
  • LEUKOCYTE DNA
  • MAMMALIAN DNA

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