TY - JOUR
T1 - Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease
AU - Fitzsimons, Carlos P.
AU - van Bodegraven, Emma
AU - Schouten, Marijn
AU - Lardenoije, Roy
AU - Kompotis, Konstantinos
AU - Kenis, Gunter
AU - van den Hurk, Mark
AU - Boks, Marco P.
AU - Biojone, Caroline
AU - Joca, Samia
AU - Steinbusch, Harry W. M.
AU - Lunnon, Katie
AU - Mastroeni, Diego F.
AU - Mill, Jonathan
AU - Lucassen, Paul J.
AU - Coleman, Paul D.
AU - van den Hove, Daniel L. A.
AU - Rutten, Bart P. F.
PY - 2014/6/25
Y1 - 2014/6/25
N2 - Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions. Previous studies had indicated that in addition to the neuropathology in Alzheimer's disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e. g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain.
AB - Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions. Previous studies had indicated that in addition to the neuropathology in Alzheimer's disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e. g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain.
KW - Adult neurogenesis
KW - Epigenetics
KW - Alzheimer's disease
KW - DNA methylation
KW - Histone modifications
KW - MicroRNAs
KW - Stem cell
KW - Induced pluripotent stem cell
U2 - 10.1186/1750-1326-9-25
DO - 10.1186/1750-1326-9-25
M3 - Article
C2 - 24964731
SN - 1750-1326
VL - 9
JO - Molecular Neurodegeneration
JF - Molecular Neurodegeneration
M1 - 25
ER -